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Proteins/UNIPROT:Q9BQS7
Plasma membrane ferroxidase that mediates the extracellular conversion of ferrous/Fe(2+) iron into its ferric/Fe(3+) form. Couples ferroportin which specifically exports ferrous/Fe(2+) iron from cells to transferrin that only binds and shuttles extracellular ferric/Fe(3+) iron throughout the body. By helping iron transfer from cells to blood mainly contributes to dietary iron absorption by the intestinal epithelium and more generally regulates iron levels in the body (By similarity)..
Function from UniProtKB (Q9BQS7), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 1 · substrate of
1 compound
1 compound.
0 reported routes1 assembled route
1 row
29 statements
29 statements · 8 reference databases · Subject: HEPH · Sources: Bgee, gene ontology, Hetionet, Human-GEM, Reactome, Rhea, UniProt, WikiPathways
3 reactions
Transported by HEPH or SLC40A1
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR09196CC BY 4.0Reference data
4iron(2+)+4proton+dioxygen4Fe(3+)+2water
Catalysed by HEPH
Reaction pageLeft to rightBalancedEC 1.16.3.1cytosol
2 names
Resolves to: HEPH