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Proteins/UNIPROT:Q86YT5
High-affinity sodium/citrate cotransporter that mediates the entry of citrate into cells, which is a critical participant of biochemical pathways. May function in various metabolic processes in which citrate has a critical role such as energy production (Krebs cycle), fatty acid synthesis, cholesterol synthesis, glycolysis, and gluconeogenesis. Transports citrate into the cell in a Na(+)-dependent manner, recognizing the trivalent form of citrate (physiological pH) rather than the divalent form. Can recognize succinate as a substrate, but its affinity for succinate is several fold lower than for citrate. The stoichiometry is probably 4 Na(+) for each carboxylate, irrespective of whether the translocated substrate is divalent or trivalent, rendering the process electrogenic. Involved in the regulation of citrate levels in the brain (By similarity)..
Function from UniProtKB (Q86YT5), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 1 · transported by
1 compound
1 compound.
0 reported routes1 assembled route
3 rows
12 statements
12 statements · 4 reference databases · Subject: SLC13A5 · Sources: Bgee, Human-GEM, Reactome, Rhea
3 reactions
citric acid+sodium(1+)citric acid+sodium(1+)
Transported by SLC13A2 or SLC13A5
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR05994CC BY 4.0Reference data
citric acid+4sodium(1+)citric acid+4sodium(1+)
Transported by SLC13A5
Reaction pageLeft to right
5 names
Resolves to: SLC13A5
Human-GEM MAR05997CC BY 4.0Reference data
citric acid+4sodium(1+)citric acid+4sodium(1+)
Transported by SLC13A5
Reaction pageDirection not assertedBalanced
Rhea RHEA:65664CC BY 4.0Reference data