Proteins/UNIPROT:P23471

PTPRZ1

ProteinUNIPROT:P23471

Protein tyrosine phosphatase that negatively regulates oligodendrocyte precursor proliferation in the embryonic spinal cord. Required for normal differentiation of the precursor cells into mature, fully myelinating oligodendrocytes. May play a role in protecting oligondendrocytes against apoptosis. May play a role in the establishment of contextual memory, probably via the dephosphorylation of proteins that are part of important signaling cascades (By similarity)..

Function from UniProtKB (P23471), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

30 statements

30 statements · 4 reference databases · Subject: PTPRZ1 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Order

ALK interacts with PTPRZ1ProteinHetionet hetionet:interacts:238-5803Inferred only
ARHGAP35 interacts with PTPRZ1ProteinHetionet hetionet:interacts:2909-5803Inferred only
CNTN1 interacts with PTPRZ1ProteinHetionet hetionet:interacts:1272-5803Inferred only
CSK interacts with PTPRZ1ProteinHetionet hetionet:interacts:1445-5803Inferred only
CTNNB1 interacts with PTPRZ1ProteinHetionet hetionet:interacts:1499-5803Inferred only
ERBB2 interacts with PTPRZ1ProteinHetionet hetionet:interacts:2064-5803Inferred only
PTPRZ1 interacts with GIT1ProteinHetionet hetionet:interacts:28964-5803Inferred only
HMGB1 interacts with PTPRZ1ProteinHetionet hetionet:interacts:3146-5803Inferred only
LCK interacts with PTPRZ1ProteinHetionet hetionet:interacts:3932-5803Inferred only
MDK interacts with PTPRZ1ProteinHetionet hetionet:interacts:4192-5803Inferred only
PTN interacts with PTPRZ1ProteinHetionet hetionet:interacts:5764-5803Inferred only
PTPRZ1 interacts with PXNProteinHetionet hetionet:interacts:5803-5829Inferred only

Show the remaining 18

PTPRZ1 interacts with TNFProteinHetionet hetionet:interacts:5803-7124Inferred only
PTPRZ1 interacts with TNRProteinHetionet hetionet:interacts:5803-7143Inferred only
PTPRZ1 interacts with WASProteinHetionet hetionet:interacts:5803-7454Inferred only
PTPRZ1 participates in Cytokine Signaling in Immune systemPathwayReactome R-HSA-1280215Inferred only
PTPRZ1 participates in Immune SystemPathwayReactome R-HSA-168256Inferred only
PTPRZ1 participates in MDK and PTN in ALK signalingPathwayReactome R-HSA-9851151Inferred only
PTPRZ1 participates in Oligodendrocyte developmentPathwayWikiPathways WP5574Inferred only
PTPRZ1 participates in Other interleukin signalingPathwayReactome R-HSA-449836Inferred only
PTPRZ1 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
PTPRZ1 participates in Signaling by ALKPathwayReactome R-HSA-201556Inferred only
PTPRZ1 participates in Signaling by InterleukinsPathwayReactome R-HSA-449147Inferred only
PTPRZ1 participates in Signaling by Receptor Tyrosine KinasesPathwayReactome R-HSA-9006934Inferred only
PTPRZ1 participates in Spinal cord injuryPathwayWikiPathways WP2431Inferred only
PTPRZ1 participates in VEGFA VEGFR2 signalingPathwayWikiPathways WP3888Inferred only
PTPRZ1 regulates negative regulation of neuron apoptotic processBiological processgene ontology P23471|GO:0043524Inferred only
PTPRZ1 regulates positive regulation of oligodendrocyte differentiationBiological processgene ontology P23471|GO:0048714Inferred only
PTPRZ1 regulates regulation of myelinationBiological processgene ontology P23471|GO:0031641Inferred only
PTPRZ1 regulates regulation of oligodendrocyte progenitor proliferationBiological processgene ontology P23471|GO:0070445Inferred only

Reactions

1 reaction

O-phospho-L-tyrosyl-[protein]+waterL-tyrosyl-[protein]+hydrogenphosphate
Catalysed by PGP or EYA2 or PTPRT or CDC14B or PTP4A3 or DUSP14 or EPM2A or EYA4 or PTPRC or PTPRF or ACP3 or PTPN2 and 71 more alternatives
Reaction pageLeft to rightBalance undeterminable

Other names

8 names

Resolves to: PTPRZ1

Also called: HTPZP2Protein-tyrosine phosphatase receptor type Z polypeptide 1Protein-tyrosine phosphatase receptor type Z polypeptide 2PTPRZPTPRZ2PTPZR-PTP-zetaR-PTP-zeta-2

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