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A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Proteins/UNIPROT:Q10469

MGAT2

Protein·UNIPROT:Q10469Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

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Plays an essential role in protein N-glycosylation. Catalyzes the transfer of N-acetylglucosamine (GlcNAc) onto the free terminal mannose moiety in the core structure of the nascent N-linked glycan chain, giving rise to the second branch in complex glycans..

Function from UniProtKB (Q10469), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

GenCC submitters' classifications

1 row

MGAT2-congenital disorder of glycosylation has a germline basis in MGAT2DiseaseGenCC HGNC:7045|MONDO:0008908Inferred only

Statements

32 statements

32 statements · 7 reference databases · Subject: MGAT2 · Sources: Bgee, Hetionet, Human-GEM, Reactome, Rhea, UniProt, WikiPathways

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MGAT2 covaries with CCDC85BProteinHetionet hetionet:covaries:11007-4247Inferred only
FCHO1 covaries with MGAT2ProteinHetionet hetionet:covaries:23149-4247Inferred only
MGAT2 covaries with TMEM200BProteinHetionet hetionet:covaries:399474-4247Inferred only
MGAT2 is expressed in jejunal mucosaAnatomyBgee ENSG00000168282Inferred only
MGAT2 participates in Asparagine N-linked glycosylationPathwayReactome R-HSA-446203Inferred only
MGAT2 participates in Defective MGAT2 causes CDG-2aPathwayReactome R-HSA-4793952Inferred only
MGAT2 participates in DiseasePathwayReactome R-HSA-1643685Inferred only
MGAT2 participates in Diseases associated with N-glycosylation of proteinsPathwayReactome R-HSA-3781860Inferred only
MGAT2 participates in Diseases of glycosylationPathwayReactome R-HSA-3781865Inferred only
MGAT2 participates in Diseases of metabolismPathwayReactome R-HSA-5668914Inferred only
MGAT2 participates in Glycosylation and related congenital defectsPathwayWikiPathways WP4521Inferred only
MGAT2 participates in Infectious diseasePathwayReactome R-HSA-5663205Inferred only

Show the remaining 20

MGAT2 participates in Late SARS-CoV-2 Infection EventsPathwayReactome R-HSA-9772573Inferred only
MGAT2 participates in Maturation of spike proteinPathwayReactome R-HSA-9694548Inferred only
MGAT2 participates in Metabolism of proteinsPathwayReactome R-HSA-392499Inferred only
MGAT2 participates in N glycan biosynthesisPathwayWikiPathways WP5153Inferred only
MGAT2 participates in N-glycan antennae elongation in the medial/trans-GolgiPathwayReactome R-HSA-975576Inferred only
MGAT2 participates in Post-translational protein modificationPathwayReactome R-HSA-597592Inferred only
MGAT2 participates in Reactions specific to the complex N-glycan synthesis pathwayPathwayReactome R-HSA-975578Inferred only
MGAT2 participates in SARS-CoV InfectionsPathwayReactome R-HSA-9679506Inferred only
MGAT2 participates in SARS-CoV-2 InfectionPathwayReactome R-HSA-9694516Inferred only
MGAT2 participates in Translation of Structural ProteinsPathwayReactome R-HSA-9694635Inferred only
MGAT2 participates in Transport to the Golgi and subsequent modificationPathwayReactome R-HSA-948021Inferred only
MGAT2 participates in Viral Infection PathwaysPathwayReactome R-HSA-9824446Inferred only
ARG1 decreases the expression of MGAT2ProteinHetionet hetionet:regulates:383-4247Inferred only
FADS1 decreases the expression of MGAT2ProteinHetionet hetionet:regulates:3992-4247Inferred only
IL2RB decreases the expression of MGAT2ProteinHetionet hetionet:regulates:3560-4247Inferred only
KLHDC2 decreases the expression of MGAT2ProteinHetionet hetionet:regulates:23588-4247Inferred only
TNFRSF21 decreases the expression of MGAT2ProteinHetionet hetionet:regulates:27242-4247Inferred only
MGAT2 requires the cofactor Mn(2+)CompoundUniProt Q10469Inferred only
CHEBI:16264 is a substrate of MGAT2CompoundHuman-GEM MAR07325Inferred only
UDP-N-acetyl-alpha-D-glucosamine is a substrate of MGAT2CompoundRhea RHEA:12941Inferred only

Reactions

2 reactions

MAM02597g+CHEBI:16264proton+MAM02507g+UDP
Catalysed by MGAT2
Reaction pageLeft to rightBalance undeterminableEC 2.4.1.143Golgi apparatus
Human-GEM MAR07325CC BY 4.0Reference data
an N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein]+UDP-N-acetyl-alpha-D-glucosamineN(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein]+UDP

Other names

5 names

Resolves to: MGAT2

Also called: Beta-1,2-N-acetylglucosaminyltransferase IIGlcNAc-T IIGNT-IIMannoside acetylglucosaminyltransferase 2N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase II

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Catalysed by MGAT2

Reaction pageLeft to rightBalance undeterminable

Rhea RHEA:12941CC BY 4.0Reference data