Proteins/UNIPROT:Q12852

MAP3K12

ProteinUNIPROT:Q12852

Part of a non-canonical MAPK signaling pathway. Activated by APOE, enhances the AP-1-mediated transcription of APP, via a MAP kinase signal transduction pathway composed of MAP2K7 and MAPK1/ERK2 and MAPK3/ERK1. May be an activator of the JNK/SAPK pathway..

Function from UniProtKB (Q12852), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

27 statements

27 statements · 4 reference databases · Subject: MAP3K12 · Sources: gene ontology, Hetionet, UniProt, WikiPathways

Order

EGFR interacts with MAP3K12ProteinHetionet hetionet:interacts:1956-7786Inferred only
MAP3K12 interacts with FRA10AC1ProteinHetionet hetionet:interacts:118924-7786Inferred only
FTL interacts with MAP3K12ProteinHetionet hetionet:interacts:2512-7786Inferred only
HSP90AA1 interacts with MAP3K12ProteinHetionet hetionet:interacts:3320-7786Inferred only
HSP90AB1 interacts with MAP3K12ProteinHetionet hetionet:interacts:3326-7786Inferred only
MAP2K4 interacts with MAP3K12ProteinHetionet hetionet:interacts:6416-7786Inferred only
MAP2K7 interacts with MAP3K12ProteinHetionet hetionet:interacts:5609-7786Inferred only
MAP3K11 interacts with MAP3K12ProteinHetionet hetionet:interacts:4296-7786Inferred only
MAPK6 interacts with MAP3K12ProteinHetionet hetionet:interacts:5597-7786Inferred only
MAP3K12 interacts with MAPK8IP1ProteinHetionet hetionet:interacts:7786-9479Inferred only
MAP3K12 interacts with MBIPProteinHetionet hetionet:interacts:51562-7786Inferred only
RGS1 interacts with MAP3K12ProteinHetionet hetionet:interacts:5996-7786Inferred only

Show the remaining 15

RPL18A interacts with MAP3K12ProteinHetionet hetionet:interacts:6142-7786Inferred only
MAP3K12 interacts with SH3RF1ProteinHetionet hetionet:interacts:57630-7786Inferred only
TGM2 interacts with MAP3K12ProteinHetionet hetionet:interacts:7052-7786Inferred only
MAP3K12 interacts with TSC22D1ProteinHetionet hetionet:interacts:7786-8848Inferred only
UBC interacts with MAP3K12ProteinHetionet hetionet:interacts:7316-7786Inferred only
MAP3K12 participates in Angiopoietin like protein 8 regulatory pathwayPathwayWikiPathways WP3915Inferred only
MAP3K12 participates in Insulin signalingPathwayWikiPathways WP481Inferred only
MAP3K12 participates in MAPK cascadePathwayWikiPathways WP422Inferred only
MAP3K12 participates in MAPK signalingPathwayWikiPathways WP382Inferred only
MAP3K12 participates in MAPK signaling and ARTD family membersPathwayWikiPathways WP5530Inferred only
MAP3K12 regulates positive regulation of DNA-templated transcriptionBiological processgene ontology Q12852|GO:0045893Inferred only
MAP3K12 regulates positive regulation of ERK1 and ERK2 cascadeBiological processgene ontology Q12852|GO:0070374Inferred only
MAP3K12 decreases the expression of CHIC2ProteinHetionet hetionet:regulates:7786-26511Inferred only
MAP3K12 increases the expression of GPX3ProteinHetionet hetionet:regulates:7786-2878Inferred only
MAP3K12 requires the cofactor magnesium(2+)CompoundUniProt Q12852Inferred only

Reactions

2 reactions

L-seryl-[protein]+ATP(4-)O-phospho-L-seryl-[protein]+ADP(3-)+hydron
Catalysed by SGK1 or CDC7 or PLK4 or STK25 or CIT or RIOK3 or MAP2K7 or CHEK1 or BCKDK or IKBKB or CASK or AURKA and 347 more alternatives
Reaction pageLeft to right

Other names

7 names

Resolves to: MAP3K12

Also called: DLKDual leucine zipper bearing kinaseLeucine-zipper protein kinaseMAPK-upstream kinaseMixed lineage kinaseMUKZPK

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