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Proteins/UNIPROT:Q13905
Guanine nucleotide-releasing protein that binds to SH3 domain of CRK and GRB2/ASH. Transduces signals from CRK to activate RAS. Involved in cell branching and adhesion mediated by BCAR1-CRK-RAPGEF1 signaling and activation of RAP1. Plays a role in the establishment of basal endothelial barrier function. Plays a role in nerve growth factor (NGF)-induced sustained activation of Rap1 and neurite outgrowth..
Function from UniProtKB (Q13905), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
62 statements
62 statements · 4 reference databases · Subject: RAPGEF1 · Sources: gene ontology, Hetionet, Reactome, WikiPathways
5 names
Resolves to: RAPGEF1