Pathway
Biosynthesis of DHA-derived sulfido conjugates
The polyunsaturated fatty acid (PUFA) ω-3 docosahexaenoic acid (DHA) is a precursor for the production of novel sulfido-peptide conjugated mediators with structural similarity to the cysteinyl-leukotrienes and with novel biological properties. They are produced from specialised proresolving mediators (SPMs) in human macrophages and are termed protectin conjugates in tissue regeneration (PCTR), resolvin conjugates in tissue regeneration (RCTR), and maresin conjugates in tissue regeneration (MCTR) because they regulate mechanisms in inflammation resolution as well as tissue regeneration (Dalli et al. 2014, 2015, 2016, Serhan et al. 2017). Their biosynthesis is descibed in this section.
What the reference databases state
Statements
2 statements
2 statements · 1 reference database · Subject: Biosynthesis of DHA-derived sulfido conjugates · Sources: Reactome
- GSTM4 participates in Biosynthesis of DHA-derived sulfido conjugatesProteinReactome R-HSA-9026395Inferred only
- LTC4S participates in Biosynthesis of DHA-derived sulfido conjugatesProteinReactome R-HSA-9026395Inferred only