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Proteins/UNIPROT:Q99665

IL12RB2

Protein·UNIPROT:Q99665

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Receptor for interleukin-12. This subunit is the signaling component coupling to the JAK2/STAT4 pathway. Promotes the proliferation of T-cells as well as NK cells. Induces the promotion of T-cells towards the Th1 phenotype by strongly enhancing IFN-gamma production.

Function from UniProtKB (Q99665), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

26 statements

26 statements · 4 reference databases · Subject: IL12RB2 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

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IL12RB2 covaries with RAVER2ProteinHetionet hetionet:covaries:3595-55225Inferred only
IL12B interacts with IL12RB2ProteinHetionet hetionet:interacts:3593-3595Inferred only
IL12RB1 interacts with IL12RB2ProteinHetionet hetionet:interacts:3594-3595Inferred only
IL12RB2 interacts with JAK2ProteinHetionet hetionet:interacts:3595-3717Inferred only
IL12RB2 interacts with SOCS3ProteinHetionet hetionet:interacts:3595-9021Inferred only
IL12RB2 interacts with STAT4ProteinHetionet hetionet:interacts:3595-6775Inferred only
IL12RB2 participates in Cancer pathwaysPathwayWikiPathways WP5434Inferred only
IL12RB2 participates in Cytokine cytokine receptor interactionPathwayWikiPathways WP5473Inferred only
IL12RB2 participates in Cytokine Signaling in Immune systemPathwayReactome R-HSA-1280215Inferred only
IL12RB2 participates in Developmental BiologyPathwayReactome R-HSA-1266738Inferred only
IL12RB2 participates in Differentiation of naive CD4+ T cells to T helper 1 cells (Th1 cells)PathwayReactome R-HSA-9942503Inferred only
IL12RB2 participates in Differentiation of T cellsPathwayReactome R-HSA-9945266Inferred only

Show the remaining 14

IL12RB2 participates in Immune SystemPathwayReactome R-HSA-168256Inferred only
IL12RB2 participates in Inflammatory bowel disease signalingPathwayWikiPathways WP5198Inferred only
IL12RB2 participates in Integrative Analysis of Treg Glial Interactions PathwayWikiPathways WP5561Inferred only
IL12RB2 participates in Interleukin-12 family signalingPathwayReactome R-HSA-447115Inferred only
IL12RB2 participates in Interleukin-12 signalingPathwayReactome R-HSA-9020591Inferred only
IL12RB2 participates in Interleukin-35 SignallingPathwayReactome R-HSA-8984722Inferred only
IL12RB2 participates in Regulatory circuits of STAT3 signalingPathwayWikiPathways WP4538Inferred only
IL12RB2 participates in Selective expression of chemokine receptors during T cell polarizationPathwayWikiPathways WP4494Inferred only
IL12RB2 participates in Signaling by InterleukinsPathwayReactome R-HSA-449147Inferred only
IL12RB2 participates in T cell activation SARS CoV 2PathwayWikiPathways WP5098Inferred only
IL12RB2 regulates negative regulation of T-helper 1 type immune responseBiological processgene ontology Q99665|GO:0002826Inferred only
IL12RB2 regulates positive regulation of cell population proliferationBiological processgene ontology Q99665|GO:0008284Inferred only
IL12RB2 regulates positive regulation of type II interferon productionBiological processgene ontology Q99665|GO:0032729Inferred only
IL12RB2 regulates regulation of B cell proliferationBiological processgene ontology Q99665|GO:0030888Inferred only

Other names

4 names

Resolves to: IL12RB2

Also called: IL-12 receptor subunit beta-2IL-12R subunit beta-2IL-12R-beta-2IL-12RB2

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