Pathway
mRNA decay by 3' to 5' exoribonuclease
The degradation of mRNA from 3' to 5' occurs in two steps. First, the exosome exoribonuclease complex binds the 3' end of the oligoadenylated mRNA and hydrolyzes it from 3' to 5', yielding ribonucleotides having 5'-monophosphates, until a capped oligoribonucleotide remains. Second, the scavenging decapping enzyme DCPS hydrolyzes the 7-methylguanosine cap.
REACT:R-HSA-429958Reactome
What the reference databases state
Statements
16 statements
16 statements · 1 reference database · Subject: mRNA decay by 3' to 5' exoribonuclease · Sources: Reactome
- DCPS participates in mRNA decay by 3' to 5' exoribonucleaseProteinReactome R-HSA-429958Inferred only
- DIS3 participates in mRNA decay by 3' to 5' exoribonucleaseProteinReactome R-HSA-429958Inferred only
- EXOSC1 participates in mRNA decay by 3' to 5' exoribonucleaseProteinReactome R-HSA-429958Inferred only
- EXOSC2 participates in mRNA decay by 3' to 5' exoribonucleaseProteinReactome R-HSA-429958Inferred only
- EXOSC3 participates in mRNA decay by 3' to 5' exoribonucleaseProteinReactome R-HSA-429958Inferred only
- EXOSC4 participates in mRNA decay by 3' to 5' exoribonucleaseProteinReactome R-HSA-429958Inferred only
- EXOSC5 participates in mRNA decay by 3' to 5' exoribonucleaseProteinReactome R-HSA-429958Inferred only
- EXOSC6 participates in mRNA decay by 3' to 5' exoribonucleaseProteinReactome R-HSA-429958Inferred only
- EXOSC7 participates in mRNA decay by 3' to 5' exoribonucleaseProteinReactome R-HSA-429958Inferred only
- EXOSC8 participates in mRNA decay by 3' to 5' exoribonucleaseProteinReactome R-HSA-429958Inferred only
- EXOSC9 participates in mRNA decay by 3' to 5' exoribonucleaseProteinReactome R-HSA-429958Inferred only
- HBS1L participates in mRNA decay by 3' to 5' exoribonucleaseProteinReactome R-HSA-429958Inferred only
Show the remaining 4
- NT5C3B participates in mRNA decay by 3' to 5' exoribonucleaseProteinReactome R-HSA-429958Inferred only
- SKIC2 participates in mRNA decay by 3' to 5' exoribonucleaseProteinReactome R-HSA-429958Inferred only
- SKIC3 participates in mRNA decay by 3' to 5' exoribonucleaseProteinReactome R-HSA-429958Inferred only
- SKIC8 participates in mRNA decay by 3' to 5' exoribonucleaseProteinReactome R-HSA-429958Inferred only