Pathway
Alpha-oxidation of phytanate
Phytanic acid arises through ruminant metabolism of chlorophyll and enters the human diet as a constituent of dairy products. It can act as an agonist for PPAR and other nuclear hormone receptors, but its normal role in human physiology, if any, is unclear. It is catabolized via a five-step alpha-oxidation reaction sequence that yields pristanoyl-CoA, which is turn is a substrate for beta-oxidation. These reactions take place in the peroxisomal matrix and their failure is associated with Refsum disease.
REACT:R-HSA-389599Reactome
What the reference databases state
Statements
5 statements
5 statements · 1 reference database · Subject: Alpha-oxidation of phytanate · Sources: Reactome
- HACL1 participates in Alpha-oxidation of phytanateProteinReactome R-HSA-389599Inferred only
- PECR participates in Alpha-oxidation of phytanateProteinReactome R-HSA-389599Inferred only
- PHYH participates in Alpha-oxidation of phytanateProteinReactome R-HSA-389599Inferred only
- SLC25A17 participates in Alpha-oxidation of phytanateProteinReactome R-HSA-389599Inferred only
- SLC27A2 participates in Alpha-oxidation of phytanateProteinReactome R-HSA-389599Inferred only