Pathway

Transport of connexins along the secretory pathway

Connexins follow the classical secretory transport route from the ER to the plasma membrane: ER -> ERGIC -> Golgi -> TGN (Trans Golgi Network) -> PM (Plasma Membrane). All connexins assemble or oligomerize into hexameric connexons. The site of assembly varies and depends on Cx isoform, or cell type (see Koval et al., 2006).

Oligomerization of connexins has been observed during ER membrane insertion (Cx32), just after exit from the ER, in the ER-Golgi-intermediate compartment (Cx26) and inside the Trans-Golgi Network (Cx43).

Summary from Reactome (R-HSA-190827), read 2026-09-23.

REACT:R-HSA-190827Reactome

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What the reference databases state

Statements

3 statements

3 statements · 1 reference database · Subject: Transport of connexins along the secretory pathway · Sources: Reactome

Order

GJA1 participates in Transport of connexins along the secretory pathwayProteinReactome R-HSA-190827Inferred only
GJB1 participates in Transport of connexins along the secretory pathwayProteinReactome R-HSA-190827Inferred only
GJB2 participates in Transport of connexins along the secretory pathwayProteinReactome R-HSA-190827Inferred only