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Proteins/UNIPROT:P49682
[Isoform 1]: Receptor for the C-X-C chemokines CXCL9, CXCL10 and CXCL11, and mediates the proliferation, survival and angiogenic activity of human mesangial cells (HMC) through a heterotrimeric G-protein signaling pathway. Probably promotes cell chemotaxis response. Upon activation by PF4, induces activated T-lymphocyte migration mediated via downstream Ras/extracellular signal-regulated kinase (ERK) signaling..
[Isoform 2]: Receptor for the C-X-C chemokine CXCL4 and also mediates the inhibitory activities of CXCL9, CXCL10 and CXCL11 on the proliferation, survival and angiogenic activity of human microvascular endothelial cells (HMVEC) through a cAMP-mediated signaling pathway. Does not promote cell chemotaxis response. Interaction with CXCL4 or CXCL10 leads to activation of the p38MAPK pathway and contributes to inhibition of angiogenesis. Overexpression in renal cancer cells down-regulates expression of the anti-apoptotic protein HMOX1 and promotes apoptosis..
[Isoform 3]: Mediates the activity of CXCL11.
Function from UniProtKB (P49682), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
41 statements
41 statements · 4 reference databases · Subject: CXCR3 · Sources: gene ontology, Hetionet, Reactome, WikiPathways
8 names
Resolves to: CXCR3