Proteins/UNIPROT:Q5JSP0

FGD3

ProteinUNIPROT:Q5JSP0

Promotes the formation of filopodia. May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape (By similarity)..

Function from UniProtKB (Q5JSP0), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

19 statements

19 statements · 3 reference databases · Subject: FGD3 · Sources: gene ontology, Hetionet, Reactome

Order

FXYD3 covaries with FGD3ProteinHetionet hetionet:covaries:5349-89846Inferred only
SUSD3 covaries with FGD3ProteinHetionet hetionet:covaries:203328-89846Inferred only
CDC42 interacts with FGD3ProteinHetionet hetionet:interacts:89846-998Inferred only
UBC interacts with FGD3ProteinHetionet hetionet:interacts:7316-89846Inferred only
FGD3 participates in CDC42 GTPase cyclePathwayReactome R-HSA-9013148Inferred only
FGD3 participates in Cell death signalling via NRAGE, NRIF and NADEPathwayReactome R-HSA-204998Inferred only
FGD3 participates in Death Receptor SignalingPathwayReactome R-HSA-73887Inferred only
FGD3 participates in G alpha (12/13) signalling eventsPathwayReactome R-HSA-416482Inferred only
FGD3 participates in GPCR downstream signallingPathwayReactome R-HSA-388396Inferred only
FGD3 participates in NRAGE signals death through JNKPathwayReactome R-HSA-193648Inferred only
FGD3 participates in p75 NTR receptor-mediated signallingPathwayReactome R-HSA-193704Inferred only
FGD3 participates in RHO GTPase cyclePathwayReactome R-HSA-9012999Inferred only

Show the remaining 7

FGD3 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
FGD3 participates in Signaling by GPCRPathwayReactome R-HSA-372790Inferred only
FGD3 participates in Signaling by Rho GTPasesPathwayReactome R-HSA-194315Inferred only
FGD3 participates in Signaling by Rho GTPases, Miro GTPases and RHOBTB3PathwayReactome R-HSA-9716542Inferred only
FGD3 regulates regulation of cell shapeBiological processgene ontology Q5JSP0|GO:0008360Inferred only
FGD3 regulates regulation of GTPase activityBiological processgene ontology Q5JSP0|GO:0043087Inferred only
FGD3 regulates regulation of small GTPase mediated signal transductionBiological processgene ontology Q5JSP0|GO:0051056Inferred only

Other names

3 names

Resolves to: FGD3

Also called: FYVE, RhoGEF and PH domain-containing protein 3ZFYVE5Zinc finger FYVE domain-containing protein 5

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