Proteins/UNIPROT:Q969M7

UBE2F

ProteinUNIPROT:Q969M7

Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. Together with the E3 ubiquitin ligase RNF7/RBX2, specifically neddylates cullin-5 (CUL5). Does not neddylate CUL1, CUL2, CUL3, CUL4A or CUL4B. Mediates neddylation of the CUL9-RBX1 complex..

(Microbial infection) Following infection by HIV-1 virus, participates to HIV-1 Vif protein-mediated ubiquitination and degradation of APOBEC3G by mediating neddylation of cullin-5 (CUL5)..

Function from UniProtKB (Q969M7), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

21 statements

21 statements · 3 reference databases · Subject: UBE2F · Sources: Hetionet, Reactome, WikiPathways

Order

CUL5 interacts with UBE2FProteinHetionet hetionet:interacts:140739-8065Inferred only
DCUN1D1 interacts with UBE2FProteinHetionet hetionet:interacts:140739-54165Inferred only
DCUN1D2 interacts with UBE2FProteinHetionet hetionet:interacts:140739-55208Inferred only
DCUN1D3 interacts with UBE2FProteinHetionet hetionet:interacts:123879-140739Inferred only
EIF2B4 interacts with UBE2FProteinHetionet hetionet:interacts:140739-8890Inferred only
NEDD8 interacts with UBE2FProteinHetionet hetionet:interacts:140739-4738Inferred only
PRAME interacts with UBE2FProteinHetionet hetionet:interacts:140739-23532Inferred only
RNF34 interacts with UBE2FProteinHetionet hetionet:interacts:140739-80196Inferred only
TYK2 interacts with UBE2FProteinHetionet hetionet:interacts:140739-7297Inferred only
UBA3 interacts with UBE2FProteinHetionet hetionet:interacts:140739-9039Inferred only
UBC interacts with UBE2FProteinHetionet hetionet:interacts:140739-7316Inferred only
WDR77 interacts with UBE2FProteinHetionet hetionet:interacts:140739-79084Inferred only

Show the remaining 9

UBE2F participates in 2q37 copy number variation syndromePathwayWikiPathways WP5224Inferred only
UBE2F participates in Adaptive Immune SystemPathwayReactome R-HSA-1280218Inferred only
UBE2F participates in Antigen processing: Ubiquitination & Proteasome degradationPathwayReactome R-HSA-983168Inferred only
UBE2F participates in Class I MHC mediated antigen processing & presentationPathwayReactome R-HSA-983169Inferred only
UBE2F participates in Immune SystemPathwayReactome R-HSA-168256Inferred only
UBE2F participates in Integrated breast cancer pathwayPathwayWikiPathways WP1984Inferred only
UBE2F participates in Metabolism of proteinsPathwayReactome R-HSA-392499Inferred only
UBE2F participates in NeddylationPathwayReactome R-HSA-8951664Inferred only
UBE2F participates in Post-translational protein modificationPathwayReactome R-HSA-597592Inferred only

Reactions

1 reaction

MAM00204c+ATP+MAM03105cMAM00214c+AMP+diphosphate(3-)
Catalysed by RNF40 & RNF20 or SAE1 & UBA2 or RING1 & RNF2 or HECW1 or MYCBP2 or MYLIP or UBE3C or RNF216 or UBR7 or RNF14 or UBR2

Other names

6 names

Resolves to: UBE2F

Also called: NCE2NEDD8 carrier protein UBE2FNEDD8 protein ligase UBE2FNEDD8-conjugating enzyme 2RING-type E3 NEDD8 transferase UBE2FUbiquitin-conjugating enzyme E2 F

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