Compound
alfacalcidol
A member of the class of D3 vitamins that is calciol in which the hydrogen at the 1α position is replaced by a hydroxy group. It is an active metabolite of cholecalciferol, which performs important functions in regulation of the calcium balance and the bone metabolism.
Definition from ChEBI (CHEBI:31186), read 2026-09-23. CC BY 4.0.
Structure
- Class
- Organic compound
- Formula
- C27H44O2
- Mass
- 400.647 g/mol
- Charge
- 0
- InChIKey
- OFHCOWSQAMBJIW-AVJTYSNKSA-N
- SMILES
- [H][C@@]12CC[C@]([H])([C@H](C)CCCC(C)C)[C@@]1(C)CCC/C2=CC=C1C[C@@H](O)C[C@H](O)C1=C
- Look it up
- ChEBIBy InChIKey
Identity from ChEBI. Not evidence.
What it touches on the way
Mechanistic reach
1 entity
1 entities reached.
0 reported hops1 assembled from the scaffold
What the reference databases state
Chemical structure
- alfacalcidol has the functional parent calciolCompoundChEBI CHEBI:31186Inferred only
Statements
1 statement
1 statement · 1 reference database · Subject: alfacalcidol · Sources: Rhea
- alfacalcidol is metabolised by CYP2R1ProteinRhea RHEA:49272Inferred only
Reactions
2 reactions
alfacalcidol+2reduced [adrenodoxin]+dioxygen+2hydroncalcitriol+2oxidized [adrenodoxin]+water
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:46592CC BY 4.0Reference data
alfacalcidol+reduced [NADPH--hemoprotein reductase]+dioxygencalcitriol+oxidized [NADPH--hemoprotein reductase]+water+hydron
Catalysed by CYP2R1
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:49272CC BY 4.0Reference data
Other names
13 names
Resolves to: alfacalcidol
- Also called
- (5Z,7E)-(1S,3R)-9,10-seco-5,7,10(19)-cholestatriene-1,3-diol(5Z,7E)-9,10-seco-5,7,10(19)-cholestatrien-1alpha,3beta-diol(5Z,7E)-9,10-seco-5,7,10(19)-cholestatrien-1α,3β-diol1alpha-hydroxy-vitamin D31alpha-hydroxycholecalciferol1alpha-hydroxyvitamin D31α-hydroxy-vitamin D31α-hydroxycholecalciferol1α-hydroxyvitamin D39,10-secocholesta-5,7,10(19)-triene-1alpha,3beta-diol9,10-secocholesta-5,7,10(19)-triene-1α,3β-diol
- Systematic name
- (1S,3R,5Z,7E)-9,10-secocholesta-5,7,10-triene-1,3-diol
- Sold as
- Alsiodol