Proteins/UNIPROT:Q7L1T6

CYB5R4

ProteinUNIPROT:Q7L1T6

NADH-cytochrome b5 reductase involved in endoplasmic reticulum stress response pathway. Plays a critical role in protecting pancreatic beta-cells against oxidant stress, possibly by protecting the cell from excess buildup of reactive oxygen species (ROS). Reduces a variety of substrates in vitro, such as cytochrome c, feericyanide and methemoglobin.

Function from UniProtKB (Q7L1T6), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

8 statements

8 statements · 4 reference databases · Subject: CYB5R4 · Sources: Hetionet, Reactome, UniProt, WikiPathways

Order

PAXIP1 interacts with CYB5R4ProteinHetionet hetionet:interacts:22976-51167Inferred only
CYB5R4 participates in Erythrocytes take up carbon dioxide and release oxygenPathwayReactome R-HSA-1237044Inferred only
CYB5R4 participates in O2/CO2 exchange in erythrocytesPathwayReactome R-HSA-1480926Inferred only
CYB5R4 participates in Oxidation by cytochrome P450PathwayWikiPathways WP43Inferred only
CYB5R4 participates in Transport of small moleculesPathwayReactome R-HSA-382551Inferred only
BCL7B increases the expression of CYB5R4ProteinHetionet hetionet:regulates:9275-51167Inferred only
RBM34 increases the expression of CYB5R4ProteinHetionet hetionet:regulates:23029-51167Inferred only
CYB5R4 requires the cofactor FAD(3-)CompoundUniProt Q7L1T6Inferred only

Reactions

2 reactions

2MAM01823c+NADH(2-)2MAM01825c+proton+NAD(+)
Catalysed by CYB5R4 or CYB5R3 or CYB5R1 or CYB5R2 or CYB5RL
Reaction pageReversibleBalance undeterminableEC 1.6.2.2cytosol
Human-GEM MAR03992CC BY 4.0Reference data
2Fe(III)-[cytochrome b5]+NADH(2-)2Fe(II)-[cytochrome b5]

Other names

5 names

Resolves to: CYB5R4

Also called: b5+b5Rcb5/cb5RFlavohemoprotein b5/b5RN-terminal cytochrome b5 and cytochrome b5 oxidoreductase domain-containing proteinNCB5OR

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