Proteins/UNIPROT:Q6BCY4

CYB5R2

ProteinUNIPROT:Q6BCY4

NADH-cytochrome b5 reductases are involved in desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction (By similarity). Responsible for NADH-dependent lucigenin chemiluminescence in spermatozoa by reducing both lucigenin and 2-[4-iodophenyl]-3-[4-nitrophenyl]-5-[2,4-disulfophenyl]-2H tetrazolium monosodium salt (WST-1)..

Function from UniProtKB (Q6BCY4), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

9 statements

9 statements · 4 reference databases · Subject: CYB5R2 · Sources: Hetionet, Reactome, UniProt, WikiPathways

Order

REX1BD covaries with CYB5R2ProteinHetionet hetionet:covaries:51700-55049Inferred only
COIL interacts with CYB5R2ProteinHetionet hetionet:interacts:51700-8161Inferred only
FFAR2 interacts with CYB5R2ProteinHetionet hetionet:interacts:2867-51700Inferred only
TRIP13 interacts with CYB5R2ProteinHetionet hetionet:interacts:51700-9319Inferred only
CYB5R2 participates in Erythrocytes take up carbon dioxide and release oxygenPathwayReactome R-HSA-1237044Inferred only
CYB5R2 participates in O2/CO2 exchange in erythrocytesPathwayReactome R-HSA-1480926Inferred only
CYB5R2 participates in Oxidation by cytochrome P450PathwayWikiPathways WP43Inferred only
CYB5R2 participates in Transport of small moleculesPathwayReactome R-HSA-382551Inferred only
CYB5R2 requires the cofactor FAD(3-)CompoundUniProt Q6BCY4Inferred only

Reactions

2 reactions

2MAM01823c+NADH(2-)2MAM01825c+proton+NAD(+)
Catalysed by CYB5R4 or CYB5R3 or CYB5R1 or CYB5R2 or CYB5RL
Reaction pageReversibleBalance undeterminableEC 1.6.2.2cytosol
Human-GEM MAR03992CC BY 4.0Reference data
2Fe(III)-[cytochrome b5]+NADH(2-)2Fe(II)-[cytochrome b5]

Other names

1 name

Resolves to: CYB5R2

Also called: b5R.2

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