Papers/PMID:35728870
L-5-hydroxytryptophan promotes antitumor immunity by inhibiting PD-L1 inducible expression.
Journal for immunotherapy of cancer2022The record
1 finding · 1 compound · 1 endpoint
What it reported
How to read these marksWhat moved
1 finding
5-hydroxy-L-tryptophan — inhibits CD274
SpeculativeGrade F, Speculative. Mechanistic inference, no evidence found, or evidence weakened below D.Finding“In syngeneic mouse tumor models, treatment with 100 mg/kg L-5-HTP (intraperitoneal) inhibited PD-L1 expression and exhibited antitumor effect.”
Quoted verbatim from L-5-hydroxytryptophan promotes antitumor immunity by inhibiting PD-L1 inducible expression.. - Study
- animal · not in humans
- Dose
- 100 mg/kg intraperitoneal
- Population
- syngeneic mouse tumor models
L-5-hydroxytryptophan promotes antitumor immunity by inhibiting PD-L1 inducible expression.2022PMID:35728870Permalink