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Proteins/UNIPROT:P51164
The beta subunit of the gastric H(+)/K(+) ATPase pump which transports H(+) ions in exchange for K(+) ions across the apical membrane of parietal cells. Plays a structural and regulatory role in the assembly and membrane targeting of a functionally active pump (By similarity). Within a transport cycle, the transfer of a H(+) ion across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation of the alpha subunit that shifts the pump conformation from inward-facing (E1) to outward-facing state (E2). Interacts with the phosphorylation domain of the alpha subunit and functions as a ratchet, stabilizing the lumenal-open E2 conformation and preventing the reverse reaction of the transport cycle (By similarity)..
Function from UniProtKB (P51164), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 1 · transported by
1 compound
1 compound.
0 reported routes1 assembled route
11 statements
11 statements · 3 reference databases · Subject: ATP4B · Sources: Hetionet, Human-GEM, Reactome
2 reactions
ATP+water+potassium atom+2sodium(1+)ADP+proton+potassium atom+2sodium(1+)+phosphate(3-)
Reaction pageLeft to rightBalancedEC 7.2.2.19cytosol, extracellular space
Human-GEM MAR01444CC BY 4.0Reference data
ATP+
2 names
Resolves to: ATP4B
Reaction pageLeft to rightBalancedEC 7.2.2.19cytosol, extracellular space
Human-GEM MAR08892CC BY 4.0Reference data