Proteins/UNIPROT:Q9NS15

LTBP3

ProteinUNIPROT:Q9NS15

Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space. Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta..

Function from UniProtKB (Q9NS15), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

4 rows

Acromicric dysplasia has a germline basis in LTBP3DiseaseGenCC HGNC:6716|MONDO:0007055Inferred only
brachyolmia-amelogenesis imperfecta syndrome has a germline basis in LTBP3DiseaseGenCC HGNC:6716|MONDO:0011018Inferred only
geleophysic dysplasia has a germline basis in LTBP3DiseaseGenCC HGNC:6716|MONDO:0000127Inferred only
geleophysic dysplasia 3 has a germline basis in LTBP3DiseaseGenCC HGNC:6716|MONDO:0054722Inferred only

Statements

35 statements

35 statements · 4 reference databases · Subject: LTBP3 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Order

NR2F6 covaries with LTBP3ProteinHetionet hetionet:covaries:2063-4054Inferred only
LTBP3 covaries with RCOR2ProteinHetionet hetionet:covaries:283248-4054Inferred only
SMC1A covaries with LTBP3ProteinHetionet hetionet:covaries:4054-8243Inferred only
CACNA1A interacts with LTBP3ProteinHetionet hetionet:interacts:4054-773Inferred only
CCNG1 interacts with LTBP3ProteinHetionet hetionet:interacts:4054-900Inferred only
LTBP3 interacts with GORASP2ProteinHetionet hetionet:interacts:26003-4054Inferred only
ITGB5 interacts with LTBP3ProteinHetionet hetionet:interacts:3693-4054Inferred only
LTBP3 interacts with PELI2ProteinHetionet hetionet:interacts:4054-57161Inferred only
LTBP3 interacts with PIK3R2ProteinHetionet hetionet:interacts:4054-5296Inferred only
LTBP3 interacts with PRPF40AProteinHetionet hetionet:interacts:4054-55660Inferred only
LTBP3 interacts with RAC1ProteinHetionet hetionet:interacts:4054-5879Inferred only
LTBP3 interacts with TGFB1ProteinHetionet hetionet:interacts:4054-7040Inferred only

Show the remaining 23

LTBP3 interacts with TGFB2ProteinHetionet hetionet:interacts:4054-7042Inferred only
LTBP3 interacts with TGFB3ProteinHetionet hetionet:interacts:4054-7043Inferred only
LTBP3 participates in Elastic fibre formationPathwayReactome R-HSA-1566948Inferred only
LTBP3 participates in Extracellular matrix organizationPathwayReactome R-HSA-1474244Inferred only
LTBP3 participates in Molecules associated with elastic fibresPathwayReactome R-HSA-2129379Inferred only
LTBP3 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
LTBP3 participates in Signaling by TGF-beta Receptor ComplexPathwayReactome R-HSA-170834Inferred only
LTBP3 participates in Signaling by TGFB family membersPathwayReactome R-HSA-9006936Inferred only
LTBP3 participates in TGF beta receptor signaling in skeletal dysplasiasPathwayWikiPathways WP4816Inferred only
LTBP3 participates in TGF-beta receptor signaling activates SMADsPathwayReactome R-HSA-2173789Inferred only
LTBP3 regulates positive regulation of mesenchymal stem cell differentiationBiological processgene ontology Q9NS15|GO:2000741Inferred only
LTBP3 regulates positive regulation of mesenchymal stem cell proliferationBiological processgene ontology Q9NS15|GO:1902462Inferred only
AGTR1 increases the expression of LTBP3ProteinHetionet hetionet:regulates:185-4054Inferred only
ATG12 decreases the expression of LTBP3ProteinHetionet hetionet:regulates:9140-4054Inferred only
CELSR3 increases the expression of LTBP3ProteinHetionet hetionet:regulates:1951-4054Inferred only
DNAJC1 decreases the expression of LTBP3ProteinHetionet hetionet:regulates:64215-4054Inferred only
GNA11 decreases the expression of LTBP3ProteinHetionet hetionet:regulates:2767-4054Inferred only
IKBKE decreases the expression of LTBP3ProteinHetionet hetionet:regulates:9641-4054Inferred only
MTSS1 increases the expression of LTBP3ProteinHetionet hetionet:regulates:9788-4054Inferred only
PIK3CA increases the expression of LTBP3ProteinHetionet hetionet:regulates:5290-4054Inferred only
PNP decreases the expression of LTBP3ProteinHetionet hetionet:regulates:4860-4054Inferred only
RPS6KB1 increases the expression of LTBP3ProteinHetionet hetionet:regulates:6198-4054Inferred only
SRSF3 decreases the expression of LTBP3ProteinHetionet hetionet:regulates:6428-4054Inferred only

Other names

2 names

Resolves to: LTBP3

Also called: Latent-transforming growth factor beta-binding protein 3LTBP-3

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