Proteins/UNIPROT:Q8WWG9

KCNE4

ProteinUNIPROT:Q8WWG9

Ancillary protein that functions as a regulatory subunit of the voltage-gated potassium (Kv) channel complex composed of pore-forming and potassium-conducting alpha subunits and of regulatory beta subunits. KCNE4 beta subunit modulates the gating kinetics and enhances stability of the channel complex. Associates with KCNQ1/KVLTQ1 alpha subunit to inhibit potassium currents..

[Isoform 2]: May inhibit KCNQ4-mediated potassium currents..

Function from UniProtKB (Q8WWG9), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

12 statements

12 statements · 3 reference databases · Subject: KCNE4 · Sources: gene ontology, Hetionet, Reactome

Order

KCNA1 interacts with KCNE4ProteinHetionet hetionet:interacts:23704-3736Inferred only
KCND2 interacts with KCNE4ProteinHetionet hetionet:interacts:23704-3751Inferred only
KCNQ1 interacts with KCNE4ProteinHetionet hetionet:interacts:23704-3784Inferred only
PRKCA interacts with KCNE4ProteinHetionet hetionet:interacts:23704-5578Inferred only
TSNAX interacts with KCNE4ProteinHetionet hetionet:interacts:23704-7257Inferred only
KCNE4 participates in Cardiac conductionPathwayReactome R-HSA-5576891Inferred only
KCNE4 participates in Muscle contractionPathwayReactome R-HSA-397014Inferred only
KCNE4 participates in Phase 2 - plateau phasePathwayReactome R-HSA-5576893Inferred only
KCNE4 participates in Phase 3 - rapid repolarisationPathwayReactome R-HSA-5576890Inferred only
KCNE4 regulates regulation of heart rate by cardiac conductionBiological processgene ontology Q8WWG9|GO:0086091Inferred only
KCNE4 regulates regulation of ventricular cardiac muscle cell membrane repolarizationBiological processgene ontology Q8WWG9|GO:0060307Inferred only
SWAP70 decreases the expression of KCNE4ProteinHetionet hetionet:regulates:23075-23704Inferred only

Other names

4 names

Resolves to: KCNE4

Also called: Minimum potassium ion channel-related peptide 3MinK-related peptide 3MiRP3Potassium channel subunit beta MiRP3

← Every protein Find it in the graph →