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Proteins/UNIPROT:Q9NY47

CACNA2D2

Protein·UNIPROT:Q9NY47

Open in the graph

The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q-type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) and possibly T-type (CACNA1G). Overexpression induces apoptosis..

Function from UniProtKB (Q9NY47), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

GenCC submitters' classifications

2 rows

cerebellar atrophy with seizures and variable developmental delay has a germline basis in CACNA2D2DiseaseGenCC HGNC:1400|MONDO:0032788Inferred only
complex neurodevelopmental disorder has a germline basis in CACNA2D2DiseaseGenCC HGNC:1400|MONDO:0100038Inferred only

Statements

26 statements

26 statements · 3 reference databases · Subject: CACNA2D2 · Sources: Hetionet, Reactome, WikiPathways

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CACNA2D2 covaries with FZD5ProteinHetionet hetionet:covaries:7855-9254Inferred only
NKX1-2 covaries with CACNA2D2ProteinHetionet hetionet:covaries:390010-9254Inferred only
CACNA2D2 covaries with NPTXRProteinHetionet hetionet:covaries:23467-9254Inferred only
PRR7 covaries with CACNA2D2ProteinHetionet hetionet:covaries:80758-9254Inferred only
CACNA2D2 covaries with SOCS1ProteinHetionet hetionet:covaries:8651-9254Inferred only
TAF7 covaries with CACNA2D2ProteinHetionet hetionet:covaries:6879-9254Inferred only
CACNA2D2 covaries with ZNF26ProteinHetionet hetionet:covaries:7574-9254Inferred only
CACNA2D2 covaries with ZNF710ProteinHetionet hetionet:covaries:374655-9254Inferred only
ZNF711 covaries with CACNA2D2ProteinHetionet hetionet:covaries:7552-9254Inferred only
UBC interacts with CACNA2D2ProteinHetionet hetionet:interacts:7316-9254Inferred only
CACNA2D2 participates in Adrenaline,noradrenaline inhibits insulin secretionPathwayReactome R-HSA-400042Inferred only
CACNA2D2 participates in Arrhythmogenic right ventricular cardiomyopathyPathwayWikiPathways WP2118Inferred only

Show the remaining 14

CACNA2D2 participates in Cardiac conductionPathwayReactome R-HSA-5576891Inferred only
CACNA2D2 participates in Integration of energy metabolismPathwayReactome R-HSA-163685Inferred only
CACNA2D2 participates in MAPK signalingPathwayWikiPathways WP382Inferred only
CACNA2D2 participates in MetabolismPathwayReactome R-HSA-1430728Inferred only
CACNA2D2 participates in Muscle contractionPathwayReactome R-HSA-397014Inferred only
CACNA2D2 participates in Neuronal SystemPathwayReactome R-HSA-112316Inferred only
CACNA2D2 participates in Phase 0 - rapid depolarisationPathwayReactome R-HSA-5576892Inferred only
CACNA2D2 participates in Phase 2 - plateau phasePathwayReactome R-HSA-5576893Inferred only
CACNA2D2 participates in Presynaptic depolarization and calcium channel openingPathwayReactome R-HSA-112308Inferred only
CACNA2D2 participates in Regulation of insulin secretionPathwayReactome R-HSA-422356Inferred only
CACNA2D2 participates in Sensory PerceptionPathwayReactome R-HSA-9709957Inferred only
CACNA2D2 participates in Sensory processing of soundPathwayReactome R-HSA-9659379Inferred only
CACNA2D2 participates in Sensory processing of sound by inner hair cells of the cochleaPathwayReactome R-HSA-9662360Inferred only
CACNA2D2 participates in Transmission across Chemical SynapsesPathwayReactome R-HSA-112315Inferred only

Other names

3 names

Resolves to: CACNA2D2

Also called: KIAA0558Voltage-dependent calcium channel subunit alpha-2/delta-2Voltage-gated calcium channel subunit alpha-2/delta-2

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