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Proteins/UNIPROT:Q9UJ90

KCNE5

Protein·UNIPROT:Q9UJ90

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Potassium channel ancillary subunit that is essential for generation of some native K(+) currents by virtue of formation of heteromeric ion channel complex with voltage-gated potassium (Kv) channel pore-forming alpha subunits. Functions as an inhibitory beta-subunit of the repolarizing cardiac potassium ion channel KCNQ1..

Function from UniProtKB (Q9UJ90), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

14 statements

14 statements · 3 reference databases · Subject: KCNE5 · Sources: gene ontology, Hetionet, Reactome

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APP interacts with KCNE5ProteinHetionet hetionet:interacts:23630-351Inferred only
KCNE5 participates in Cardiac conductionPathwayReactome R-HSA-5576891Inferred only
KCNE5 participates in Muscle contractionPathwayReactome R-HSA-397014Inferred only
KCNE5 participates in Phase 2 - plateau phasePathwayReactome R-HSA-5576893Inferred only
KCNE5 participates in Phase 3 - rapid repolarisationPathwayReactome R-HSA-5576890Inferred only
KCNE5 regulates negative regulation of potassium ion export across plasma membraneBiological processgene ontology Q9UJ90|GO:1903765Inferred only
KCNE5 regulates negative regulation of potassium ion transmembrane transportBiological processgene ontology Q9UJ90|GO:1901380Inferred only
KCNE5 regulates positive regulation of potassium ion transmembrane transportBiological processgene ontology Q9UJ90|GO:1901381Inferred only
KCNE5 regulates regulation of atrial cardiac muscle cell membrane repolarizationBiological processgene ontology Q9UJ90|GO:0060372Inferred only
KCNE5 regulates regulation of heart contractionBiological processgene ontology Q9UJ90|GO:0008016Inferred only
KCNE5 regulates regulation of heart rate by cardiac conductionBiological processgene ontology Q9UJ90|GO:0086091Inferred only
KCNE5 regulates regulation of membrane repolarizationBiological processgene ontology Q9UJ90|GO:0060306Inferred only

Show the remaining 2

KCNE5 regulates regulation of potassium ion transmembrane transportBiological processgene ontology Q9UJ90|GO:1901379Inferred only
KCNE5 regulates regulation of ventricular cardiac muscle cell membrane repolarizationBiological processgene ontology Q9UJ90|GO:0060307Inferred only

Other names

5 names

Resolves to: KCNE5

Also called: AMME syndrome candidate gene 2 proteinAMMECR2KCNE1LPotassium channel subunit beta MiRP4Potassium voltage-gated channel subfamily E member 1-like protein

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