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Proteins/UNIPROT:Q5T442

GJC2

Protein·UNIPROT:Q5T442

Open in the graph

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a role in myelination in central and peripheral nervous systems..

Function from UniProtKB (Q5T442), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

GenCC submitters' classifications

3 rows

hereditary spastic paraplegia 44 has a germline basis in GJC2DiseaseGenCC HGNC:17494|MONDO:0013179Inferred only
leukodystrophy, hypomyelinating, 2 has a germline basis in GJC2DiseaseGenCC HGNC:17494|MONDO:0012125Inferred only
lymphatic malformation 3 has a germline basis in GJC2DiseaseGenCC HGNC:17494|MONDO:0013278Inferred only

Statements

5 statements

5 statements · 1 reference database · Subject: GJC2 · Sources: Reactome

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GJC2 participates in Gap junction assemblyPathwayReactome R-HSA-190861Inferred only
GJC2 participates in Gap junction traffickingPathwayReactome R-HSA-190828Inferred only
GJC2 participates in Gap junction trafficking and regulationPathwayReactome R-HSA-157858Inferred only
GJC2 participates in Membrane TraffickingPathwayReactome R-HSA-199991Inferred only
GJC2 participates in Vesicle-mediated transportPathwayReactome R-HSA-5653656Inferred only

Other names

6 names

Resolves to: GJC2

Also called: Connexin-46.6Connexin-47Cx46.6Cx47Gap junction alpha-12 proteinGJA12

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