Proteins/UNIPROT:Q9Y6H8

GJA3

ProteinUNIPROT:Q9Y6H8

Structural component of lens fiber gap junctions. Gap junctions are dodecameric channels that connect the cytoplasm of adjoining cells (By similarity). They are formed by the docking of two hexameric hemichannels, one from each cell membrane. Small molecules and ions diffuse from one cell to a neighboring cell via the central pore..

Function from UniProtKB (Q9Y6H8), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

4 rows

cataract 14 multiple types has a germline basis in GJA3DiseaseGenCC HGNC:4277|MONDO:0011162Inferred only
early-onset nuclear cataract has a germline basis in GJA3DiseaseGenCC HGNC:4277|MONDO:0020376Inferred only
early-onset posterior polar cataract has a germline basis in GJA3DiseaseGenCC HGNC:4277|MONDO:0020378Inferred only
pulverulent cataract has a germline basis in GJA3DiseaseGenCC HGNC:4277|MONDO:0011430Inferred only

Statements

16 statements

16 statements · 3 reference databases · Subject: GJA3 · Sources: Hetionet, Reactome, WikiPathways

Order

CCDC57 covaries with GJA3ProteinHetionet hetionet:covaries:2700-284001Inferred only
COBL covaries with GJA3ProteinHetionet hetionet:covaries:23242-2700Inferred only
POFUT3 covaries with GJA3ProteinHetionet hetionet:covaries:2700-84750Inferred only
CAV1 interacts with GJA3ProteinHetionet hetionet:interacts:2700-857Inferred only
GJA1 interacts with GJA3ProteinHetionet hetionet:interacts:2697-2700Inferred only
GJA3 interacts with MIPProteinHetionet hetionet:interacts:2700-4284Inferred only
GJA3 interacts with PRKCGProteinHetionet hetionet:interacts:2700-5582Inferred only
GJA3 interacts with TJP1ProteinHetionet hetionet:interacts:2700-7082Inferred only
GJA3 interacts with UBCProteinHetionet hetionet:interacts:2700-7316Inferred only
GJA3 participates in 1q21 1 copy number variation syndromePathwayWikiPathways WP4905Inferred only
GJA3 participates in Calcium regulation in cardiac cellsPathwayWikiPathways WP536Inferred only
GJA3 participates in Gap junction assemblyPathwayReactome R-HSA-190861Inferred only

Show the remaining 4

GJA3 participates in Gap junction traffickingPathwayReactome R-HSA-190828Inferred only
GJA3 participates in Gap junction trafficking and regulationPathwayReactome R-HSA-157858Inferred only
GJA3 participates in Membrane TraffickingPathwayReactome R-HSA-199991Inferred only
GJA3 participates in Vesicle-mediated transportPathwayReactome R-HSA-5653656Inferred only

Other names

2 names

Resolves to: GJA3

Also called: Connexin-46Cx46

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