Proteins/UNIPROT:P23588

EIF4B

ProteinUNIPROT:P23588

Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F.

Function from UniProtKB (P23588), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

80 statements

80 statements · 4 reference databases · Subject: EIF4B · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Order

FRAS1 covaries with EIF4BProteinHetionet hetionet:covaries:1975-80144Inferred only
PPP1R9A covaries with EIF4BProteinHetionet hetionet:covaries:1975-55607Inferred only
EIF4B interacts with ACDProteinHetionet hetionet:interacts:1975-65057Inferred only
ARRB1 interacts with EIF4BProteinHetionet hetionet:interacts:1975-408Inferred only
ARRB2 interacts with EIF4BProteinHetionet hetionet:interacts:1975-409Inferred only
CAMK2D interacts with EIF4BProteinHetionet hetionet:interacts:1975-817Inferred only
CASP3 interacts with EIF4BProteinHetionet hetionet:interacts:1975-836Inferred only
CSNK2A1 interacts with EIF4BProteinHetionet hetionet:interacts:1457-1975Inferred only
EIF4B interacts with CUL3ProteinHetionet hetionet:interacts:1975-8452Inferred only
EIF4B interacts with EIF3AProteinHetionet hetionet:interacts:1975-8661Inferred only
EIF4B interacts with EIF3BProteinHetionet hetionet:interacts:1975-8662Inferred only
EIF4B interacts with EIF4A3ProteinHetionet hetionet:interacts:1975-9775Inferred only

Show the remaining 68

EIF4B interacts with EIF4EProteinHetionet hetionet:interacts:1975-1977Inferred only
EIF4B interacts with MAGOHProteinHetionet hetionet:interacts:1975-4116Inferred only
EIF4B interacts with NELL1ProteinHetionet hetionet:interacts:1975-4745Inferred only
EIF4B interacts with PABPC1ProteinHetionet hetionet:interacts:1975-26986Inferred only
EIF4B interacts with PAK2ProteinHetionet hetionet:interacts:1975-5062Inferred only
EIF4B interacts with PLK1ProteinHetionet hetionet:interacts:1975-5347Inferred only
EIF4B interacts with RPS6KA1ProteinHetionet hetionet:interacts:1975-6195Inferred only
EIF4B interacts with RPS6KB1ProteinHetionet hetionet:interacts:1975-6198Inferred only
EIF4B interacts with SMURF1ProteinHetionet hetionet:interacts:1975-57154Inferred only
EIF4B interacts with TERF1ProteinHetionet hetionet:interacts:1975-7013Inferred only
EIF4B interacts with TINF2ProteinHetionet hetionet:interacts:1975-26277Inferred only
EIF4B interacts with UBCProteinHetionet hetionet:interacts:1975-7316Inferred only
EIF4B interacts with XPO7ProteinHetionet hetionet:interacts:1975-23039Inferred only
EIF4B interacts with YWHAEProteinHetionet hetionet:interacts:1975-7531Inferred only
EIF4B interacts with YWHAZProteinHetionet hetionet:interacts:1975-7534Inferred only
EIF4B participates in Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43SPathwayReactome R-HSA-72662Inferred only
EIF4B participates in Cap-dependent Translation InitiationPathwayReactome R-HSA-72737Inferred only
EIF4B participates in Deadenylation of mRNAPathwayReactome R-HSA-429947Inferred only
EIF4B participates in Deadenylation-dependent mRNA decayPathwayReactome R-HSA-429914Inferred only
EIF4B participates in Developmental BiologyPathwayReactome R-HSA-1266738Inferred only
EIF4B participates in Effect of dasatinib on the BCR ABL signaling pathwayPathwayWikiPathways WP5493Inferred only
EIF4B participates in Eukaryotic Translation InitiationPathwayReactome R-HSA-72613Inferred only
EIF4B participates in Focal adhesion PI3K Akt mTOR signalingPathwayWikiPathways WP3932Inferred only
EIF4B participates in GTP hydrolysis and joining of the 60S ribosomal subunitPathwayReactome R-HSA-72706Inferred only
EIF4B participates in Interferon type I signalingPathwayWikiPathways WP585Inferred only
EIF4B participates in L13a-mediated translational silencing of Ceruloplasmin expressionPathwayReactome R-HSA-156827Inferred only
EIF4B participates in M-decay: degradation of maternal mRNAs by maternally stored factorsPathwayReactome R-HSA-9820841Inferred only
EIF4B participates in Maternal to zygotic transition (MZT)PathwayReactome R-HSA-9816359Inferred only
EIF4B participates in Metabolism of proteinsPathwayReactome R-HSA-392499Inferred only
EIF4B participates in Metabolism of RNAPathwayReactome R-HSA-8953854Inferred only
EIF4B participates in MTOR signallingPathwayReactome R-HSA-165159Inferred only
EIF4B participates in mTORC1-mediated signallingPathwayReactome R-HSA-166208Inferred only
EIF4B participates in Orexin receptor pathwayPathwayWikiPathways WP5094Inferred only
EIF4B participates in Perturbations to host cell autophagy induced by SARS CoV 2 proteinsPathwayWikiPathways WP4936Inferred only
EIF4B participates in PI3K Akt signalingPathwayWikiPathways WP4172Inferred only
EIF4B participates in Pleural mesotheliomaPathwayWikiPathways WP5087Inferred only
EIF4B participates in Ribosomal scanning and start codon recognitionPathwayReactome R-HSA-72702Inferred only
EIF4B participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
EIF4B participates in TranslationPathwayReactome R-HSA-72766Inferred only
EIF4B participates in Translation factorsPathwayWikiPathways WP107Inferred only
EIF4B participates in Translation inhibitors in chronically activated PDGFRA cellsPathwayWikiPathways WP4566Inferred only
EIF4B participates in Translation initiation complex formationPathwayReactome R-HSA-72649Inferred only
EIF4B participates in Z-decay: degradation of maternal mRNAs by zygotically expressed factorsPathwayReactome R-HSA-9820865Inferred only
EIF4B regulates regulation of translational initiationBiological processgene ontology P23588|GO:0006446Inferred only
EIF4B decreases the expression of AMDHD2ProteinHetionet hetionet:regulates:1975-51005Inferred only
EIF4B increases the expression of ARID5BProteinHetionet hetionet:regulates:1975-84159Inferred only
EIF4B decreases the expression of ASCC3ProteinHetionet hetionet:regulates:1975-10973Inferred only
EIF4B decreases the expression of B4GAT1ProteinHetionet hetionet:regulates:1975-11041Inferred only
EIF4B decreases the expression of BLCAPProteinHetionet hetionet:regulates:1975-10904Inferred only
EIF4B decreases the expression of CDK7ProteinHetionet hetionet:regulates:1975-1022Inferred only
EIF4B decreases the expression of COASYProteinHetionet hetionet:regulates:1975-80347Inferred only
EIF4B decreases the expression of GTPBP8ProteinHetionet hetionet:regulates:1975-29083Inferred only
EIF4B increases the expression of HPProteinHetionet hetionet:regulates:1975-3240Inferred only
EIF4B decreases the expression of HSD17B10ProteinHetionet hetionet:regulates:1975-3028Inferred only
EIF4B decreases the expression of IFRD2ProteinHetionet hetionet:regulates:1975-7866Inferred only
ISL1 decreases the expression of EIF4BProteinHetionet hetionet:regulates:3670-1975Inferred only
EIF4B decreases the expression of KCTD5ProteinHetionet hetionet:regulates:1975-54442Inferred only
EIF4B decreases the expression of KRT7ProteinHetionet hetionet:regulates:1975-3855Inferred only
EIF4B decreases the expression of LYPLA1ProteinHetionet hetionet:regulates:1975-10434Inferred only
EIF4B decreases the expression of MRPS2ProteinHetionet hetionet:regulates:1975-51116Inferred only
EIF4B decreases the expression of PRUNE2ProteinHetionet hetionet:regulates:1975-158471Inferred only
EIF4B decreases the expression of RPS4Y1ProteinHetionet hetionet:regulates:1975-6192Inferred only
EIF4B increases the expression of SESN1ProteinHetionet hetionet:regulates:1975-27244Inferred only
EIF4B decreases the expression of SYPL1ProteinHetionet hetionet:regulates:1975-6856Inferred only
EIF4B decreases the expression of TERF2IPProteinHetionet hetionet:regulates:1975-54386Inferred only
EIF4B decreases the expression of TMEM109ProteinHetionet hetionet:regulates:1975-79073Inferred only
EIF4B decreases the expression of TOMM34ProteinHetionet hetionet:regulates:1975-10953Inferred only
EIF4B decreases the expression of YKT6ProteinHetionet hetionet:regulates:1975-10652Inferred only

Other names

2 names

Resolves to: EIF4B

Also called: eIF-4BEukaryotic translation initiation factor 4B

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