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Papers/PMID:32145098

Melatonin and its analogues for the prevention of postoperative delirium: A systematic review and meta-analysis.

Journal of pineal research2020The record

1 finding drawn from this paper, on 1 compound across 1 endpoint.

melatonin

What it reported

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What moved

1 finding

melatonin — decreases incidence of postoperative delirium
PreliminaryGrade D, Preliminary. Non-human or in vitro only.Finding
“Melatonin administered less than 5 elimination half-lives before the surgery significantly reduced the POD incidence (OR = 0.31, 95% CI 0.19-0.49, P < .00001).”
Quoted verbatim from Melatonin and its analogues for the prevention of postoperative delirium: A systematic review and meta-analysis..
Study

meta-analysis
Population

Adult surgical patients; subgroup pooled analysis (6 RCTs, 2 cohort studies, 1 case-control study) restricted to melatonin administered less than 5 elimination half-lives before surgery
Effect 0.31 odds ratio, 95% CI 0.19 to 0.49
Melatonin and its analogues for the prevention of postoperative delirium: A systematic review and meta-analysis.2020PMID:32145098