Papers/PMID:32145098
Melatonin and its analogues for the prevention of postoperative delirium: A systematic review and meta-analysis.
Journal of pineal research2020The record
1 finding · 1 compound · 1 endpoint
What it reported
How to read these marksWhat moved
1 finding
melatonin — decreases incidence of postoperative delirium
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.Finding“Melatonin administered less than 5 elimination half-lives before the surgery significantly reduced the POD incidence (OR = 0.31, 95% CI 0.19-0.49, P < .00001).”
Quoted verbatim from Melatonin and its analogues for the prevention of postoperative delirium: A systematic review and meta-analysis.. - Study
- meta-analysis
- Population
- Adult surgical patients; subgroup pooled analysis (6 RCTs, 2 cohort studies, 1 case-control study) restricted to melatonin administered less than 5 elimination half-lives before surgery
Effect 0.31 odds ratio, 95% CI 0.19 to 0.49
Melatonin and its analogues for the prevention of postoperative delirium: A systematic review and meta-analysis.2020PMID:32145098Permalink