Papers/PMID:21151885
A mitochondrial superoxide signal triggers increased longevity in Caenorhabditis elegans.
PLoS biology2010The record
1 finding · 1 compound · 1 endpoint
What it reported
How to read these marksWhat moved
1 finding
L-ascorbic acid — decreases organism lifespan
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.Findingreplicated ×1“Treatment with 1 mM vitamin C also significantly shortened the lifespan of both isp-1 and nuo-6 mutants without affecting the wild type (Table S1).”
Quoted verbatim from A mitochondrial superoxide signal triggers increased longevity in Caenorhabditis elegans.. - Study
- animal · not in humans
- Dose
- 1 mM in nematode growth medium
- Population
- Long-lived Caenorhabditis elegans mitochondrial mutants isp-1(qm150) and nuo-6(qm200), raised from hatching on plates containing 1 mM vitamin C; wild-type animals were reported unaffected
A mitochondrial superoxide signal triggers increased longevity in Caenorhabditis elegans.2010PMID:21151885Permalink