PapersPMID:39519584
Sodium Benzoate Induces Fat Accumulation and Reduces Lifespan via the SKN-1/Nrf2 Signaling Pathway: Evidence from the Caenorhabditis elegans Model.
- 01 · findings
- 2
- 02 · compound
- 1
- 03 · endpoints
- 2
- 04 · null
- 0
What moved
2 findingsHow to read these marks →sodium benzoate — decreases organism lifespan
insufficientFindingreplicated ×1
“Lifespan analysis also demonstrated that SB significantly reduced lifespan in wild-type worms, even at low concentrations.”
Quoted verbatim from Sodium Benzoate Induces Fat Accumulation and Reduces Lifespan via the SKN-1/Nrf2 Signaling Pathway: Evidence from the Caenorhabditis elegans Model. - Study
- animal · not in humans
- Dose studied
- 0.0004-0.1% SB, in liquid culture or on NGM agar
- Population
- wild-type Caenorhabditis elegans exposed to SB concentrations 0.0004-0.1%
sodium benzoate — inhibits POU2F3
insufficientFinding
“Moreover, SB inhibited the nuclear localization of SKN-1 under oxidative stress conditions.”
Quoted verbatim from Sodium Benzoate Induces Fat Accumulation and Reduces Lifespan via the SKN-1/Nrf2 Signaling Pathway: Evidence from the Caenorhabditis elegans Model. - Study
- animal · not in humans
- Population
- wild-type Caenorhabditis elegans under oxidative stress conditions
Study record
- Read under
- sodium benzoate
- Design
- animal study, in vivo
- Species
- animal
- Population
- Caenorhabditis elegans wild-type N2 and skn-1(zj15) loss-of-function mutant worms
- Participants
- not recorded
- Comparator
- another dose
- Duration
- 3 days
- Endpoints measured
- 25
- Record
- extracted
- Readings recorded
- 3