Papers/PMID:39519584
Sodium Benzoate Induces Fat Accumulation and Reduces Lifespan via the SKN-1/Nrf2 Signaling Pathway: Evidence from the Caenorhabditis elegans Model.
Nutrients2024The record
2 findings · 1 compound · 2 endpoints
What it reported
How to read these marksWhat moved
2 findings
sodium benzoate — decreases organism lifespan
SpeculativeGrade F, Speculative. Mechanistic inference, or no evidence found.Findingreplicated ×1“Lifespan analysis also demonstrated that SB significantly reduced lifespan in wild-type worms, even at low concentrations.”
Quoted verbatim from Sodium Benzoate Induces Fat Accumulation and Reduces Lifespan via the SKN-1/Nrf2 Signaling Pathway: Evidence from the Caenorhabditis elegans Model.. - Study
- animal · not in humans
- Dose
- 0.0004-0.1% SB, in liquid culture or on NGM agar
- Population
- wild-type Caenorhabditis elegans exposed to SB concentrations 0.0004-0.1%
Sodium Benzoate Induces Fat Accumulation and Reduces Lifespan via the SKN-1/Nrf2 Signaling Pathway: Evidence from the Caenorhabditis elegans Model.2024PMID:39519584Permalink
sodium benzoate — inhibits POU2F3
SpeculativeGrade F, Speculative. Mechanistic inference, or no evidence found.Finding“Moreover, SB inhibited the nuclear localization of SKN-1 under oxidative stress conditions.”
Quoted verbatim from Sodium Benzoate Induces Fat Accumulation and Reduces Lifespan via the SKN-1/Nrf2 Signaling Pathway: Evidence from the Caenorhabditis elegans Model.. - Study
- animal · not in humans
- Population
- wild-type Caenorhabditis elegans under oxidative stress conditions
Sodium Benzoate Induces Fat Accumulation and Reduces Lifespan via the SKN-1/Nrf2 Signaling Pathway: Evidence from the Caenorhabditis elegans Model.2024PMID:39519584Permalink