Papers/PMID:27683245
Antioxidants reveal an inverted U-shaped dose-response relationship between reactive oxygen species levels and the rate of aging in Caenorhabditis elegans.
Aging cell2017The record
1 finding · 1 compound · 1 endpoint
What it reported
How to read these marksWhat moved
1 finding
L-ascorbic acid — decreases organism lifespan
InsufficientEvidence strength: insufficient. Mechanistic inference, no evidence found, or evidence weakened below very limited.Findingreplicated ×1“VitC however produced only a very mild lifespan shortening at the lower concentration tested (5 mm).”
Quoted verbatim from Antioxidants reveal an inverted U-shaped dose-response relationship between reactive oxygen species levels and the rate of aging in Caenorhabditis elegans.. - Study
- animal · not in humans
- Dose
- 5 mM in growth medium
- Population
- Wild-type Caenorhabditis elegans on nematode growth medium plates containing DMSO, vitamin C at the lower tested concentration (5 mM) only; mean lifespan versus untreated control
Antioxidants reveal an inverted U-shaped dose-response relationship between reactive oxygen species levels and the rate of aging in Caenorhabditis elegans.2017PMID:27683245Permalink