Papers/PMID:40341867
Effect of 7-day dietary supplementation with grape seed extract on cardiac autonomic and hemodynamic responses in elevated and stage 1 hypertension.
Clinical physiology and functional imaging2025The record
3 findings · 1 compound · 3 endpoints · 1 null
What it reported
How to read these marksWhat moved
2 findings
Vitis vinifera — decreases mean arterial pressure
LimitedEvidence strength: limited. Human evidence with several recorded weaknesses, or a design that tops out at limited.Finding“Our results indicated that GSE decreased resting DBP (75 ± 2 vs. 71 ± 3) and MAP (91 ± 2 vs. 88 ± 3) compared to the placebo (DBP:71 ± 3 vs. 74 ± 3; MAP: 89 ± 2 vs. 90 ± 2).”
Quoted verbatim from Effect of 7-day dietary supplementation with grape seed extract on cardiac autonomic and hemodynamic responses in elevated and stage 1 hypertension.. - Study
- crossover
- Population
- Males with elevated and stage 1 hypertension in a double-blind placebo-controlled cross-over trial of short-term dietary grape seed extract supplementation with a 1-week wash-out; resting MAP
Effect of 7-day dietary supplementation with grape seed extract on cardiac autonomic and hemodynamic responses in elevated and stage 1 hypertension.2025PMID:40341867Permalink
Vitis vinifera — decreases diastolic blood pressure (setting unspecified)
LimitedEvidence strength: limited. Human evidence with several recorded weaknesses, or a design that tops out at limited.Findingreplicated ×1“Our results indicated that GSE decreased resting DBP (75 ± 2 vs. 71 ± 3) and MAP (91 ± 2 vs. 88 ± 3) compared to the placebo (DBP:71 ± 3 vs. 74 ± 3; MAP: 89 ± 2 vs. 90 ± 2).”
Quoted verbatim from Effect of 7-day dietary supplementation with grape seed extract on cardiac autonomic and hemodynamic responses in elevated and stage 1 hypertension.. - Study
- crossover
- Population
- Males with elevated and stage 1 hypertension in a double-blind placebo-controlled cross-over trial of short-term dietary grape seed extract supplementation with a 1-week wash-out
Effect of 7-day dietary supplementation with grape seed extract on cardiac autonomic and hemodynamic responses in elevated and stage 1 hypertension.2025PMID:40341867Permalink
What did not
1 finding
Vitis vinifera — no detected effect on systolic blood pressure (setting unspecified)
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.FindingNull result“There were no differences on the HR, SV, CO, SBP, and HRV between placebo and GSE treatments.”
Quoted verbatim from Effect of 7-day dietary supplementation with grape seed extract on cardiac autonomic and hemodynamic responses in elevated and stage 1 hypertension.. - Study
- crossover
- Population
- Males with elevated and stage 1 hypertension in a double-blind placebo-controlled cross-over trial of short-term dietary grape seed extract supplementation with a 1-week wash-out
Effect of 7-day dietary supplementation with grape seed extract on cardiac autonomic and hemodynamic responses in elevated and stage 1 hypertension.2025PMID:40341867Permalink