Papers/PMID:33460048
Immediate-release methylphenidate for attention deficit hyperactivity disorder (ADHD) in adults.
The Cochrane database of systematic reviews2021The record
1 finding · 1 compound · 1 endpoint · 1 null
What it reported
How to read these marksEvery finding here is a null result.
What did not
1 finding
methylphenidate — no detected effect on hamilton Depression Rating Scale (HDRS) total score
PreliminaryGrade D, Preliminary. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.FindingNull result“There is no clear evidence of an effect on anxiety (MD -0.20, 95% CI -4.84 to 4.44; 1 trial, 19 participants; change scores; Hamilton Anxiety Scale (HAM-A; scored from 0 to 56); very low-certainty evidence) or depression (MD 2.80, 95% CI -0.09 to 5.69; 1 trial, 19 participants; change scores; Hamilton Depression Scale (HAM-D; scored from 0 to 52); very low-certainty evidence) in analyses comparing IR methylphenidate with placebo.”
Quoted verbatim from Immediate-release methylphenidate for attention deficit hyperactivity disorder (ADHD) in adults.. - Study
- RCT
- Participants
- 19
- Population
- adults with ADHD, immediate-release methylphenidate versus placebo; secondary outcome (depression)
Effect 2.8 mean difference, 95% CI -0.09 to 5.69
Immediate-release methylphenidate for attention deficit hyperactivity disorder (ADHD) in adults.2021PMID:33460048Permalink