Papers/PMID:37653795
The effects of paroxetine therapy on depressive symptom and motor function in the treatment of depression with Parkinson's disease: A meta-analysis.
Medicine2023The record
2 findings · 1 compound · 2 endpoints
What it reported
How to read these marksWhat moved
2 findings
paroxetine — decreases hamilton Depression Rating Scale (HDRS) total score
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.Finding“The HAMD score showed significant decrease in the paroxetine treatment group compared to control group (SMD -2.14, 95% CI -2.73 to -1.56, P <.00001).”
Quoted verbatim from The effects of paroxetine therapy on depressive symptom and motor function in the treatment of depression with Parkinson's disease: A meta-analysis.. - Study
- meta-analysis
- Dose
- 20 mg/d in most trials
- Population
- Patients with depression and idiopathic Parkinson's disease; paroxetine added to background anti-parkinsonian drug therapy versus that therapy alone (or placebo in 3 trials); 25 trials, 2126 patients
Effect -2.14 standardised mean difference, 95% CI -2.73 to -1.56
The effects of paroxetine therapy on depressive symptom and motor function in the treatment of depression with Parkinson's disease: A meta-analysis.2023PMID:37653795Permalink
paroxetine — increases antidepressant treatment response rate
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.Finding“Paroxetine therapy for dPD markedly increased the antidepressant response rate (OR 3.62, 95% CI 2.63 to 4.98, P <.00001).”
Quoted verbatim from The effects of paroxetine therapy on depressive symptom and motor function in the treatment of depression with Parkinson's disease: A meta-analysis.. - Study
- meta-analysis
- Dose
- 20 mg/d in most trials
- Population
- Patients with depression and idiopathic Parkinson's disease; paroxetine added to background anti-parkinsonian drug therapy versus that therapy alone (or placebo in 3 trials); 22 trials, 1808 participants
Effect 3.62 odds ratio, 95% CI 2.63 to 4.98
The effects of paroxetine therapy on depressive symptom and motor function in the treatment of depression with Parkinson's disease: A meta-analysis.2023PMID:37653795Permalink