PapersPMID:26066335
Chronic Supplementation of Curcumin Enhances the Efficacy of Antidepressants in Major Depressive Disorder: A Randomized, Double-Blind, Placebo-Controlled Pilot Study.
- 01 · findings
- 3
- 02 · compound
- 1
- 03 · endpoints
- 3
- 04 · null
- 0
curcumin- Dose studied, every finding
- 1000 mg/day (2 capsules)
- Population, every finding
- adult men (31-59 years) with major depressive disorder, continuing their existing antidepressant medication regimen in both curcumin and placebo arms (adjunctive therapy)
What moved
3 findingsHow to read these marks →curcumin — decreases Hamilton Depression Rating Scale (HDRS) total score
very limitedFinding
“Chronic supplementation with curcumin produced significant antidepressant behavioral response in depressed patients by reduction of 17-item Hamilton Depression Rating Scale and Montgomery-Asberg Depression Rating Scale scores.”
Quoted verbatim from Chronic Supplementation of Curcumin Enhances the Efficacy of Antidepressants in Major Depressive Disorder: A Randomized, Double-Blind, Placebo-Controlled Pilot Study. - Study
- RCT
- Duration
- 6 weeks
curcumin — decreases cortisol concentration
very limitedFinding
“Furthermore, curcumin decreases inflammatory cytokines interleukin 1β and tumor necrosis factor α level, increases plasma brain-derived neurotrophic factor levels, and decreases salivary cortisol concentrations compared with placebo group.”
Quoted verbatim from Chronic Supplementation of Curcumin Enhances the Efficacy of Antidepressants in Major Depressive Disorder: A Randomized, Double-Blind, Placebo-Controlled Pilot Study. - Study
- RCT
- Duration
- 6 weeks
curcumin — decreases tumour necrosis factor alpha concentration
very limitedFindingreplicated ×6
“Furthermore, curcumin decreases inflammatory cytokines interleukin 1β and tumor necrosis factor α level, increases plasma brain-derived neurotrophic factor levels, and decreases salivary cortisol concentrations compared with placebo group.”
Quoted verbatim from Chronic Supplementation of Curcumin Enhances the Efficacy of Antidepressants in Major Depressive Disorder: A Randomized, Double-Blind, Placebo-Controlled Pilot Study. - Study
- RCT
- Duration
- 6 weeks
Study record
- Read under
- curcumin
- Design
- randomised controlled trial
- Species
- human
- Population
- adult men (31-59 years) with major depressive disorder, on ongoing antidepressant medication
- Participants
- 108
- Comparator
- placebo
- Duration
- 42 days
- Endpoints measured
- 6
- Record
- extracted
- Readings recorded
- 2