9-cis-retinol

Three steps

• (7Z,10Z,13Z,16Z,19Z)-docosapentaenoateReach from here →
  1. Lecithin Retinol Acyltransferase (9-Cis)
  2. 1-Acyl-sn-glycero-3-phosphocholine acylhydrolase
  3. (10Z)-heptadecenoic acid formation

  Catalysed by LYPLA1, LYPLA2, PLA2G4A, PLB1 and 6 morecytosol, extracellular spaceOne of 12 routes

• (7Z,10Z,13Z,16Z)-docosatetraenoateReach from here →
  1. Lecithin Retinol Acyltransferase (9-Cis)
  2. 1-Acyl-sn-glycero-3-phosphocholine acylhydrolase
  3. (10Z)-heptadecenoic acid formation

  Catalysed by LYPLA1, LYPLA2, PLA2G4A, PLB1 and 6 morecytosol, extracellular spaceOne of 12 routes

• pristanoyl-CoAReach from here →
  1. Lecithin Retinol Acyltransferase (9-Cis)
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. fatty-acid-CoA ligase

  Catalysed by LPCAT4, LPCAT3, LPCAT2, LPCAT1 and 1 morecytosolOne of 2 routes

• a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholineReach from here →
  1. Lecithin Retinol Acyltransferase (9-Cis)
  2. 1-Acyl-sn-glycero-3-phosphocholine acylhydrolase
  3. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + H2O = a 2,3-saturated aldehyde + sn-glycerol 3-phosphocholine

  Catalysed by LYPLA1, LYPLA2, PLA2G4A, PLB1 and 8 morecytosol

• undecanoyl-CoAReach from here →
  1. Lecithin Retinol Acyltransferase (9-Cis)
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. medium-chain acyl-CoA ligase (undecylic acid)

  Catalysed by LPCAT4, LPCAT3, LPCAT2, LPCAT1 and 6 morecytosolOne of 3 routes

• (5Z,8Z,11Z)-eicosatrienoateReach from here →
  1. Lecithin Retinol Acyltransferase (9-Cis)
  2. 1-Acyl-sn-glycero-3-phosphocholine acylhydrolase
  3. (10Z)-heptadecenoic acid formation

  Catalysed by LYPLA1, LYPLA2, PLA2G4A, PLB1 and 6 morecytosol, extracellular spaceOne of 12 routes

• tricosanoateReach from here →
  1. Lecithin Retinol Acyltransferase (9-Cis)
  2. 1-Acyl-sn-glycero-3-phosphocholine acylhydrolase
  3. (10Z)-heptadecenoic acid formation

  Catalysed by LYPLA1, LYPLA2, PLA2G4A, PLB1 and 6 morecytosol, extracellular spaceOne of 12 routes

• (5Z)-tetradecenoyl-CoAReach from here →
  1. Lecithin Retinol Acyltransferase (9-Cis)
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (physeteric acid)

  Catalysed by LPCAT4, LPCAT3, LPCAT2, LPCAT1 and 8 morecytosolOne of 8 routes

• (3E)-decenoyl-CoAReach from here →
  1. Lecithin Retinol Acyltransferase (9-Cis)
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. Fatty Acid Beta Oxidation (C12:1->C10:1), Mitochondrial

  Catalysed by LPCAT4, LPCAT3, LPCAT2, LPCAT1 and 4 morecytosol, mitochondrial matrix

• (2R,6)-dimethylheptanoyl-CoAReach from here →
  1. Lecithin Retinol Acyltransferase (9-Cis)
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. acetyl-CoA C-acyltransferase (3-oxo-4(R),8-dimethyl-nonanoyl-CoA)

  Catalysed by LPCAT4, LPCAT3, LPCAT2, LPCAT1 and 3 morecytosol, mitochondrial matrix

• (7Z)-hexadecenoyl-CoAReach from here →
  1. Lecithin Retinol Acyltransferase (9-Cis)
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (7-palmitoleic acid)

  Catalysed by LPCAT4, LPCAT3, LPCAT2, LPCAT1 and 8 morecytosolOne of 8 routes

• tricosanoyl-CoAReach from here →
  1. Lecithin Retinol Acyltransferase (9-Cis)
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (tricosanoic acid)

  Catalysed by LPCAT4, LPCAT3, LPCAT2, LPCAT1 and 8 morecytosolOne of 4 routes