(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA

Three steps

• (2E,5Z)-tetradecadienoyl-CoAReach from here →
  1. (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (physeteric acid)
  3. medium-chain acyl-CoA dehydrogenase (5-tetradecenoyl-CoA)

  Catalysed by BAAT, ACOT6, SLC27A2, ACSL4 and 10 morecytosol, mitochondrial matrixOne of 4 routes

• (2E,7Z)-hexadecadienoyl-CoAReach from here →
  1. (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (7-palmitoleic acid)
  3. medium-chain acyl-CoA dehydrogenase (7-hexadecenoyl-CoA)

  Catalysed by BAAT, ACOT6, SLC27A2, ACSL4 and 10 morecytosol, mitochondrial matrixOne of 4 routes

• cholesteryl (11Z)-octadecenoateReach from here →
  1. (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA hydrolase
  2. Transport of 11-Octadecenoyl Carnitine into the Mitochondrial Matrix
  3. (11Z)-octadecenoyl-CoA + cholesterol = cholesteryl (11Z)-octadecenoate + CoA

  Catalysed by BAAT, ACOT6, CPT1A, CPT1C and 2 morecytosol

• 17R-hydroxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoateReach from here →
  1. fatty acyl-CoA desaturase (N-C22:5CoA -> N-C22:6CoA)
  2. (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA hydrolase
  3. (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + AH2 + O2 = 17R-hydroxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate + A + H2O

  Catalysed by BAAT, ACOT6, PTGS2peroxisome, cytosol

• 13-hydroxy-(4Z,7Z,10Z,14E,16Z,19Z)-docosahexaenoateReach from here →
  1. fatty acyl-CoA desaturase (N-C22:5CoA -> N-C22:6CoA)
  2. (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA hydrolase
  3. (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + AH2 + O2 = 13-hydroxy-(4Z,7Z,10Z,14E,16Z,19Z)-docosahexaenoate + A + H2O

  Catalysed by BAAT, ACOT6, PTGS2peroxisome, cytosol

• taurochenodeoxycholateReach from here →
  1. (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA hydrolase
  2. Propanoyl-CoA:acetyl-CoA C-acyltransferase
  3. 3alpha,7alpha-dihydroxy-5beta-cholanoyl-CoA:taurine N-choloyltransferase

  Catalysed by BAAT, ACOT6, ACAA1, SCP2 and 1 morecytosol, peroxisomeOne of 5 routes