N-(octadecanoyl)-sphinganine

Three steps

• N-hexadecanoyl-sphinganine-1-phosphoethanolamineReach from here →
  1. N-(octadecanoyl)-sphinganine + H2O = sphinganine + octadecanoate
  2. sphinganine + hexadecanoyl-CoA = N-hexadecanoylsphinganine + CoA + H(+)
  3. N-hexadecanoylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine = N-hexadecanoyl-sphinganine-1-phosphoethanolamine + a 1,2-diacyl-sn-glycerol

  Catalysed by ASAH2, CERS6, CERS5, CERS2 and 2 more

• an N-acylsphinganine-1-phosphoethanolamineReach from here →
  1. N-(octadecanoyl)-sphinganine + H2O = sphinganine + octadecanoate
  2. a fatty acyl-CoA + sphinganine = an N-acylsphinganine + CoA + H(+)
  3. an N-acylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine = an N-acylsphinganine-1-phosphoethanolamine + a 1,2-diacyl-sn-glycerol

  Catalysed by ASAH2, CERS1, CERS6, CERS5 and 3 more

• hexadecanoateReach from here →
  1. N-(octadecanoyl)-sphinganine + H2O = sphinganine + octadecanoate
  2. sphinganine + hexadecanoyl-CoA = N-hexadecanoylsphinganine + CoA + H(+)
  3. sphinganine + hexadecanoate = N-hexadecanoylsphinganine + H2O

  Catalysed by ASAH2, CERS6, CERS5, CERS2

• tricosanoateReach from here →
  1. N-(octadecanoyl)-sphinganine + H2O = sphinganine + octadecanoate
  2. (10Z)-heptadecenoic acid formation
  3. (10Z)-heptadecenoic acid formation

  Catalysed by ASAH2cytosol, extracellular spaceOne of 12 routes

• cholesteryl octadecanoateReach from here →
  1. N-(octadecanoyl)-sphinganine + H2O = sphinganine + octadecanoate
  2. long-chain-fatty-acid-CoA ligase (stearate)
  3. Acyl-CoA:cholesterol O-acyltransferase

  Catalysed by ASAH2, SLC27A2, ACSL4, ACSL3 and 6 morecytosol, endoplasmic reticulumOne of 2 routes

• N-octadecanoylhexadecasphinganineReach from here →
  1. N-(octadecanoyl)-sphinganine + H2O = sphinganine + octadecanoate
  2. long-chain-fatty-acid-CoA ligase (stearate)
  3. hexadecasphinganine + octadecanoyl-CoA = N-octadecanoylhexadecasphinganine + CoA + H(+)

  Catalysed by ASAH2, SLC27A2, ACSL4, ACSL3 and 6 morecytosol

• a 1-acyl-2-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol)Reach from here →
  1. N-(octadecanoyl)-sphinganine + H2O = sphinganine + octadecanoate
  2. long-chain-fatty-acid-CoA ligase (stearate)
  3. a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + octadecanoyl-CoA = a 1-acyl-2-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA

  Catalysed by ASAH2, SLC27A2, ACSL4, ACSL3 and 5 morecytosol

• O-octadecanoyl-(R)-carnitineReach from here →
  1. N-(octadecanoyl)-sphinganine + H2O = sphinganine + octadecanoate
  2. long-chain-fatty-acid-CoA ligase (stearate)
  3. (R)-carnitine + octadecanoyl-CoA = O-octadecanoyl-(R)-carnitine + CoA

  Catalysed by ASAH2, SLC27A2, ACSL4, ACSL3 and 5 morecytosol

• beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enineReach from here →
  1. N-(octadecanoyl)-sphinganine + H2O = sphinganine + octadecanoate
  2. N-octadecanoylsphing-4-enine + H2O = sphing-4-enine + octadecanoate
  3. beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + N-octadecanoylsphing-4-enine

  Catalysed by ASAH2, ASAH1, ACER2, GBA1

• 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholineReach from here →
  1. N-(octadecanoyl)-sphinganine + H2O = sphinganine + octadecanoate
  2. long-chain-fatty-acid-CoA ligase (stearate)
  3. 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + octadecanoyl-CoA = 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + CoA

  Catalysed by ASAH2, SLC27A2, ACSL4, ACSL3 and 5 morecytosol

• 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholineReach from here →
  1. N-(octadecanoyl)-sphinganine + H2O = sphinganine + octadecanoate
  2. long-chain-fatty-acid-CoA ligase (stearate)
  3. 2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + octadecanoyl-CoA = 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + CoA

  Catalysed by ASAH2, SLC27A2, ACSL4, ACSL3 and 5 morecytosol