L-glutamate 5-semialdehyde

Three steps

• thio-Mo-molybdopterinReach from here →
  1. L-ornithine + 2-oxoglutarate = L-glutamate 5-semialdehyde + L-glutamate
  2. transport of cysteine and ornithine (cytosol to extracellular)
  3. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O

  Catalysed by OAT, SLC7A6, MOCOSextracellular space, cytosol

• glycodeoxycholateReach from here →
  1. L-ornithine + 2-oxoglutarate = L-glutamate 5-semialdehyde + L-glutamate
  2. L-Arginine:glycine amidinotransferase
  3. Glycodeoxycholate amidohydrolase

  Catalysed by OAT, GATMcytosolOne of 2 routes

• N-tetradecanoylglycineReach from here →
  1. L-ornithine + 2-oxoglutarate = L-glutamate 5-semialdehyde + L-glutamate
  2. L-Arginine:glycine amidinotransferase
  3. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)

  Catalysed by OAT, GATM, GLYATL2cytosol

• N-eicosanoylglycinateReach from here →
  1. L-ornithine + 2-oxoglutarate = L-glutamate 5-semialdehyde + L-glutamate
  2. L-Arginine:glycine amidinotransferase
  3. eicosanoyl-CoA + glycine = N-eicosanoylglycinate + CoA + H(+)

  Catalysed by OAT, GATM, BAATcytosol

• N-docosanoylglycineReach from here →
  1. L-ornithine + 2-oxoglutarate = L-glutamate 5-semialdehyde + L-glutamate
  2. L-Arginine:glycine amidinotransferase
  3. docosanoyl-CoA + glycine = N-docosanoylglycine + CoA + H(+)

  Catalysed by OAT, GATM, BAATcytosol

• N-hexacosanoylglycineReach from here →
  1. L-ornithine + 2-oxoglutarate = L-glutamate 5-semialdehyde + L-glutamate
  2. L-Arginine:glycine amidinotransferase
  3. hexacosanoyl-CoA + glycine = N-hexacosanoylglycine + CoA + H(+)

  Catalysed by OAT, GATM, BAATcytosol

• an N(2)-acyl-L-glutamineReach from here →
  1. L-ornithine + 2-oxoglutarate = L-glutamate 5-semialdehyde + L-glutamate
  2. transport of glutamine and ornithine (cytosol to extracellular)
  3. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)

  Catalysed by OAT, SLC7A6, GLYATL1B, GLYATL1extracellular space, cytosol