L-lysine

Three steps

• an N(2)-acyl-L-glutamineReach from here →
  1. L-ornithine(out) + L-lysine(in) = L-ornithine(in) + L-lysine(out)
  2. transport of glutamine and ornithine (cytosol to extracellular)
  3. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)

  Catalysed by SLC25A2, SLC25A15, SLC7A6, GLYATL1B and 1 moreinner side of the membrane, outer side of the membrane, extracellular space, cytosol

• (7Z)-hexadecenoyl-CoAReach from here →
  1. L-lysine(in) + L-leucine(out) + Na(+)(out) = L-lysine(out) + L-leucine(in) + Na(+)(in)
  2. Acetylation of Leucine
  3. long-chain-fatty-acid-CoA ligase (7-palmitoleic acid)

  Catalysed by SLC7A7, SLC27A2, ACSL4, ACSL3 and 5 moreinner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosolOne of 8 routes

• tricosanoyl-CoAReach from here →
  1. L-lysine(in) + L-leucine(out) + Na(+)(out) = L-lysine(out) + L-leucine(in) + Na(+)(in)
  2. Acetylation of Leucine
  3. long-chain-fatty-acid-CoA ligase (tricosanoic acid)

  Catalysed by SLC7A7, SLC27A2, ACSL4, ACSL3 and 5 moreinner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosolOne of 4 routes