Catalyst

Reference

Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
ArticlesReadings of the evidence

Chemistry

ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
ProcessesWhat proteins are annotated as doing
AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

Compounds
Outcomes
Proteins
Interactions
Papers
Articles

Chemistry

Reactions
Reach

Reference layer

Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases

Atlas Graph Twin Access

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Catalyst

Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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Processes
Anatomy
Cell types
Organisms
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Reactions
Reach

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A reference for what the literature reports. Not medical advice.

Reach

progesterone

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

Inferred

Every route here is a hypothesis drawn from reference reactions (Rhea and Human-GEM), not a finding. Currency species such as water, ATP and NAD(H) never form a step. Evidence key

54 compounds within 3 steps: 10 in 1, 10 in 2, 34 in 3

Does it reach a compound?

Three steps

N(8)-acetylspermidineReach from here →
Catalysed by CYP17A1, HDAC10cytosol
an N-acetyl-L-cysteine-S-conjugateReach from here →
Catalysed by CYP17A1, ACY3cytosol
2-deoxy-D-ribose 5-phosphateReach from here →
Catalysed by CYP17A1, DERAcytosol, endoplasmic reticulum
6beta-hydroxyandrost-4-ene-3,17-dioneReach from here →
Catalysed by CYP17A1, CYP3A4, CYP3A5cytosol

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