phosphatidic acid

Three steps

• an N-acyl-(4R)-4-hydroxysphinganine-phosphocholineReach from here →
  1. Diacylglycerol Phosphate Kinase (Homo Sapiens)
  2. an N-acylsphing-4-enine + a 1,2-diacyl-sn-glycero-3-phosphocholine = a sphingomyelin + a 1,2-diacyl-sn-glycerol
  3. an N-acyl-(4R)-4-hydroxysphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = an N-acyl-(4R)-4-hydroxysphinganine-phosphocholine + a 1,2-diacyl-sn-glycerol

  Catalysed by DGKI, DGKZ, SGMS1, SGMS2nucleusOne of 2 routes

• N-hexadecanoyl-sphinganine-1-phosphoethanolamineReach from here →
  1. Diacylglycerol Phosphate Kinase (Homo Sapiens)
  2. CDP-ethanolamine + a 1,2-diacyl-sn-glycerol = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CMP + H(+)
  3. N-hexadecanoylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine = N-hexadecanoyl-sphinganine-1-phosphoethanolamine + a 1,2-diacyl-sn-glycerol

  Catalysed by DGKI, DGKZ, SELENOI, CEPT1 and 2 morenucleusOne of 2 routes

• an N-acylsphinganine-1-phosphoethanolamineReach from here →
  1. Diacylglycerol Phosphate Kinase (Homo Sapiens)
  2. CDP-ethanolamine + a 1,2-diacyl-sn-glycerol = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CMP + H(+)
  3. an N-acylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine = an N-acylsphinganine-1-phosphoethanolamine + a 1,2-diacyl-sn-glycerol

  Catalysed by DGKI, DGKZ, SELENOI, CEPT1 and 2 morenucleusOne of 2 routes

• N-hexadecanoyl-(4R)-hydroxysphinganine-1-phosphoethanolamineReach from here →
  1. Diacylglycerol Phosphate Kinase (Homo Sapiens)
  2. CDP-ethanolamine + a 1,2-diacyl-sn-glycerol = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CMP + H(+)
  3. N-hexadecanoyl-(4R)-hydroxysphinganine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine = N-hexadecanoyl-(4R)-hydroxysphinganine-1-phosphoethanolamine + a 1,2-diacyl-sn-glycerol

  Catalysed by DGKI, DGKZ, SELENOI, CEPT1 and 2 morenucleusOne of 2 routes

• an N-acyl-(4R)-4-hydroxysphinganine-1-phosphoethanolamineReach from here →
  1. Diacylglycerol Phosphate Kinase (Homo Sapiens)
  2. CDP-ethanolamine + a 1,2-diacyl-sn-glycerol = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CMP + H(+)
  3. an N-acyl-(4R)-4-hydroxysphinganine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine = an N-acyl-(4R)-4-hydroxysphinganine-1-phosphoethanolamine + a 1,2-diacyl-sn-glycerol

  Catalysed by DGKI, DGKZ, SELENOI, CEPT1 and 2 morenucleusOne of 2 routes

• hexadecanoateReach from here →
  1. Diacylglycerol Phosphate Kinase (Homo Sapiens)
  2. N-hexadecanoylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = N-hexadecanoyl-sphinganine-1-phosphocholine + a 1,2-diacyl-sn-glycerol
  3. sphinganine + hexadecanoate = N-hexadecanoylsphinganine + H2O

  Catalysed by DGKI, DGKZ, SGMS1, SGMS2 and 1 morenucleus

• tricosanoateReach from here →
  1. Diacylglycerol Phosphate Kinase (Homo Sapiens)
  2. 1,2-diacyl-sn-glycerol acylhydrolase
  3. (10Z)-heptadecenoic acid formation

  Catalysed by DGKI, DGKZ, LPLnucleus, extracellular spaceOne of 12 routes

• 1,2-dihexadecanoyl-sn-glycerolReach from here →
  1. Diacylglycerol Phosphate Kinase (Homo Sapiens)
  2. an N-acylsphing-4-enine + a 1,2-diacyl-sn-glycero-3-phosphocholine = a sphingomyelin + a 1,2-diacyl-sn-glycerol
  3. 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine = 1,2-dihexadecanoyl-sn-glycerol + a sphingomyelin

  Catalysed by DGKI, DGKZ, SGMS1, SGMS2nucleus

• 1-(9Z-octadecenoyl)-2-acyl-sn-3-glycerolReach from here →
  1. Diacylglycerol Phosphate Kinase (Homo Sapiens)
  2. an N-acylsphing-4-enine + a 1,2-diacyl-sn-glycero-3-phosphocholine = a sphingomyelin + a 1,2-diacyl-sn-glycerol
  3. 1-(9Z-octadecenoyl)-2-acyl-sn-3-glycerol + a sphingomyelin = a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine

  Catalysed by DGKI, DGKZ, SGMS1, SGMS2nucleus

• a monoacyl-sn-glycero-3-phosphocholineReach from here →
  1. Diacylglycerol Phosphate Kinase (Homo Sapiens)
  2. an N-acylsphing-4-enine + a 1,2-diacyl-sn-glycero-3-phosphocholine = a sphingomyelin + a 1,2-diacyl-sn-glycerol
  3. a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a monoacyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)

  Catalysed by DGKI, DGKZ, SGMS1, SGMS2 and 1 morenucleus

• 2-(acylamino)ethyl fatty acidReach from here →
  1. Diacylglycerol Phosphate Kinase (Homo Sapiens)
  2. an N-acylsphing-4-enine + a 1,2-diacyl-sn-glycero-3-phosphocholine = a sphingomyelin + a 1,2-diacyl-sn-glycerol
  3. an N-acylethanolamine + a 1,2-diacyl-sn-glycero-3-phosphocholine = 2-(acylamino)ethyl fatty acid + a 2-acyl-sn-glycero-3-phosphocholine

  Catalysed by DGKI, DGKZ, SGMS1, SGMS2 and 1 morenucleusOne of 2 routes

• 1-O-acyl-N-(acetyl)-sphing-4-enineReach from here →
  1. Diacylglycerol Phosphate Kinase (Homo Sapiens)
  2. an N-acylsphing-4-enine + a 1,2-diacyl-sn-glycero-3-phosphocholine = a sphingomyelin + a 1,2-diacyl-sn-glycerol
  3. N-(acetyl)-sphing-4-enine + a 1,2-diacyl-sn-glycero-3-phosphocholine = 1-O-acyl-N-(acetyl)-sphing-4-enine + a 1-acyl-sn-glycero-3-phosphocholine

  Catalysed by DGKI, DGKZ, SGMS1, SGMS2 and 1 morenucleusOne of 4 routes

• (5Z)-tetradecenoyl-CoAReach from here →
  1. Diacylglycerol Phosphate Kinase (Homo Sapiens)
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (physeteric acid)

  Catalysed by DGKI, DGKZ, DGAT1, MOGAT2 and 11 morenucleus, cytosolOne of 8 routes

• 1,2-diacyl-sn-glycero-3-phosphoethanolReach from here →
  1. Diacylglycerol Phosphate Kinase (Homo Sapiens)
  2. an N-acylsphing-4-enine + a 1,2-diacyl-sn-glycero-3-phosphocholine = a sphingomyelin + a 1,2-diacyl-sn-glycerol
  3. ethanol + a 1,2-diacyl-sn-glycero-3-phosphocholine = 1,2-diacyl-sn-glycero-3-phosphoethanol + choline

  Catalysed by DGKI, DGKZ, SGMS1, SGMS2 and 1 morenucleus

• (3E)-decenoyl-CoAReach from here →
  1. Diacylglycerol Phosphate Kinase (Homo Sapiens)
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. Fatty Acid Beta Oxidation (C12:1->C10:1), Mitochondrial

  Catalysed by DGKI, DGKZ, DGAT1, MOGAT2 and 7 morenucleus, cytosol, mitochondrial matrix

• (2R,6)-dimethylheptanoyl-CoAReach from here →
  1. Diacylglycerol Phosphate Kinase (Homo Sapiens)
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. acetyl-CoA C-acyltransferase (3-oxo-4(R),8-dimethyl-nonanoyl-CoA)

  Catalysed by DGKI, DGKZ, DGAT1, MOGAT2 and 6 morenucleus, cytosol, mitochondrial matrix

• (7Z)-hexadecenoyl-CoAReach from here →
  1. Diacylglycerol Phosphate Kinase (Homo Sapiens)
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (7-palmitoleic acid)

  Catalysed by DGKI, DGKZ, DGAT1, MOGAT2 and 11 morenucleus, cytosolOne of 8 routes

• tricosanoyl-CoAReach from here →
  1. Diacylglycerol Phosphate Kinase (Homo Sapiens)
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (tricosanoic acid)

  Catalysed by DGKI, DGKZ, DGAT1, MOGAT2 and 11 morenucleus, cytosolOne of 4 routes