acetoacetate
362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API
401 compounds within 3 steps: 15 in 1, 70 in 2, 316 in 3
Three steps
- transport of acetoacetate and pyruvate (cytosol to mitochondria)
- pyruvate:thiamin diphosphate acetaldehydetransferase (decarboxylating)
- 2-(alpha-hydroxyethyl)thiamine-diphosphate[m] + lipoamide[m] = S-acetyldihydrolipoamide[m] + thiamin-PP[m]
Catalysed by PDHA1, PDHB, PDHA2, DLATmitochondrial matrix, cytosol