cleft lip/palate
Findings
No curated finding names cleft lip/palate yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Cleft lip and palate is a fissure type embryopathy extending across the upper lip, nasal base, alveolar ridge and the hard and soft palate.
Definition from the Mondo Disease Ontology (MONDO:0016044), read 2026-09-29. CC BY 4.0.
Features
21 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Abnormality of dental eruptionHPOHP:0006292
- Very frequent (80% to 99% of cases)
- Cleft palateHPOHP:0000175
- Frequent (30% to 79% of cases)
- Delayed speech and language developmentHPOHP:0000750
- Frequent (30% to 79% of cases)
- Feeding difficulties in infancyHPOHP:0008872
- Frequent (30% to 79% of cases)
- Oral-pharyngeal dysphagiaHPOHP:0200136
- Frequent (30% to 79% of cases)
- Orofacial cleftHPOHP:0000202
- Frequent (30% to 79% of cases)
- Poor suckHPOHP:0002033
- Frequent (30% to 79% of cases)
- Recurrent otitis mediaHPOHP:0000403
- Frequent (30% to 79% of cases)
- Speech articulation difficultiesHPOHP:0009088
- Frequent (30% to 79% of cases)
- Unilateral cleft palateHPOHP:0100334
- Frequent (30% to 79% of cases)
- Velopharyngeal insufficiencyHPOHP:0000220
- Frequent (30% to 79% of cases)
- Abnormal number of permanent teethHPOHP:0011044
- Occasional (5% to 29% of cases)
Show the remaining 9
- Agenesis of lateral incisorHPOHP:0200153
- Occasional (5% to 29% of cases)
- Bilateral cleft palateHPOHP:0100337
- Occasional (5% to 29% of cases)
- Conductive hearing impairmentHPOHP:0000405
- Occasional (5% to 29% of cases)
- Dental malocclusionHPOHP:0000689
- Occasional (5% to 29% of cases)
- Hypernasal speechHPOHP:0001611
- Occasional (5% to 29% of cases)
- MalnutritionHPOHP:0004395
- Occasional (5% to 29% of cases)
Genes
7 genes
Germline variants in the gene encoding each protein, as classified by GenCC submitters, each in their own words. Limited, disputed and refuted submissions are listed too.
- RIC1HGNC:17686
- Strong · PanelApp Australia · Autosomal dominant · 2025
- ARHGEF38HGNC:25968
- Moderate · PanelApp Australia · Autosomal dominant · 2025
- PLEKHA5HGNC:30036
- Moderate · PanelApp Australia · Autosomal dominant · 2025
- PLEKHA7HGNC:27049
- Moderate · PanelApp Australia · Autosomal dominant · 2025
- AFDNHGNC:7137
- Limited · PanelApp Australia · Autosomal dominant · 2025
Where it sits
- Narrower terms (4)
Other names
4 names
Resolves to: cleft lip/palate
- Also called
- alveolar cleft lip and palatecleft lip and palatecleft lip-alveolus-palate syndromeFLP