Proteins/UNIPROT:P55196

AFDN

ProteinUNIPROT:P55196

Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs) (By similarity). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton. May play a key role in the organization of epithelial structures of the embryonic ectoderm (By similarity). Essential for the organization of adherens junctions..

Function from UniProtKB (P55196), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

10 statements

10 statements · 3 reference databases · Subject: AFDN · Sources: gene ontology, Hetionet, WikiPathways

Order

AFDN covaries with MTA1ProteinHetionet hetionet:covaries:4301-9112Inferred only
AFDN covaries with MXRA5ProteinHetionet hetionet:covaries:25878-4301Inferred only
AFDN covaries with VAV2ProteinHetionet hetionet:covaries:4301-7410Inferred only
AFDN participates in 1q21 1 copy number variation syndromePathwayWikiPathways WP4905Inferred only
AFDN participates in Ras signalingPathwayWikiPathways WP4223Inferred only
AFDN participates in VEGFA VEGFR2 signalingPathwayWikiPathways WP3888Inferred only
AFDN regulates negative regulation of cell migrationBiological processgene ontology P55196|GO:0030336Inferred only
AFDN regulates positive regulation of cell-cell adhesionBiological processgene ontology P55196|GO:0022409Inferred only
AFDN regulates positive regulation of cell-cell adhesion mediated by cadherinBiological processgene ontology P55196|GO:2000049Inferred only
AFDN regulates positive regulation of gene expressionBiological processgene ontology P55196|GO:0010628Inferred only

Other names

6 names

Resolves to: AFDN

Also called: AF-6AF6Afadin adherens junction formation factorALL1-fused gene from chromosome 6 proteinMLLT4Protein AF-6

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