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Proteins/UNIPROT:Q4ADV7

RIC1

Protein·UNIPROT:Q4ADV7

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The RIC1-RGP1 complex acts as a guanine nucleotide exchange factor (GEF), which activates RAB6A by exchanging bound GDP for free GTP, and may thereby be required for efficient fusion of endosome-derived vesicles with the Golgi compartment. The RIC1-RGP1 complex participates in the recycling of mannose-6-phosphate receptors. Required for phosphorylation and localization of GJA1. Is a regulator of procollagen transport and secretion, and is required for correct cartilage morphogenesis and development of the craniofacial skeleton..

Function from UniProtKB (Q4ADV7), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

GenCC submitters' classifications

2 rows

Catifa syndrome has a germline basis in RIC1DiseaseGenCC HGNC:17686|MONDO:0032901Inferred only
cleft lip/palate has a germline basis in RIC1DiseaseGenCC HGNC:17686|MONDO:0016044Inferred only

Statements

11 statements

11 statements · 3 reference databases · Subject: RIC1 · Sources: gene ontology, Hetionet, Reactome

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UBC interacts with RIC1ProteinHetionet hetionet:interacts:57589-7316Inferred only
RIC1 participates in Intra-Golgi and retrograde Golgi-to-ER trafficPathwayReactome R-HSA-6811442Inferred only
RIC1 participates in Intra-Golgi trafficPathwayReactome R-HSA-6811438Inferred only
RIC1 participates in Membrane TraffickingPathwayReactome R-HSA-199991Inferred only
RIC1 participates in RAB GEFs exchange GTP for GDP on RABsPathwayReactome R-HSA-8876198Inferred only
RIC1 participates in Rab regulation of traffickingPathwayReactome R-HSA-9007101Inferred only
RIC1 participates in Retrograde transport at the Trans-Golgi-NetworkPathwayReactome R-HSA-6811440Inferred only
RIC1 participates in Vesicle-mediated transportPathwayReactome R-HSA-5653656Inferred only
RIC1 regulates negative regulation of protein catabolic processBiological processgene ontology Q4ADV7|GO:0042177Inferred only
RIC1 regulates positive regulation of GTPase activityBiological processgene ontology Q4ADV7|GO:0043547Inferred only
RIC1 regulates regulation of extracellular matrix constituent secretionBiological processgene ontology Q4ADV7|GO:0003330Inferred only

Other names

6 names

Resolves to: RIC1

Also called: CIP150Connexin-43-interacting protein of 150 kDaKIAA1432Protein RIC1 homologRAB6A-GEF complex partner protein 1RIC1 homolog

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