orofacial cleft 10
MONDO:0013378Mondo
Findings
No curated finding names orofacial cleft 10 yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Any orofacial cleft in which the cause of the disease is a mutation in the SUMO1 gene.
Definition from the Mondo Disease Ontology (MONDO:0013378), read 2026-09-29. CC BY 4.0.
- Inheritance
- Sporadic
- Onset and course
- Congenital onset
HPO, annotations 2026-09-02
Features
2 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Unilateral cleft lipHPOHP:0100333
- 1 of 1 reported patient
- Unilateral cleft palateHPOHP:0100334
- 1 of 1 reported patient
Genes
1 gene
Germline variants in the gene encoding each protein, as classified by GenCC submitters, each in their own words. Limited, disputed and refuted submissions are listed too.
- SUMO1HGNC:12502
- Limited · Labcorp Genetics (formerly Invitae) · Unknown · 2020
- Limited · G2P · Autosomal dominant · 2025
Where it sits
- A kind of
Other names
4 names
Resolves to: orofacial cleft 10
- Also called
- orofacial cleft 10, isolated casesorofacial cleft caused by mutation in SUMO1orofacial cleft type 10SUMO1 orofacial cleft