acute myeloid leukemia
Findings
No curated finding names acute myeloid leukemia yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Acute myeloid leukemia (AML) is a group of neoplasms arising from precursor cells committed to the myeloid cell-line differentiation. All of them are characterized by clonal expansion of myeloid blasts. AML manifests by fever, pallor, anemia, hemorrhages and recurrent infections.
Definition from the Mondo Disease Ontology (MONDO:0018874), read 2026-09-29. CC BY 4.0.
Features
1 feature
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, hp/releases/2026-09-01.
- AnemiaMondoHP:0001903
Genes
12 genes
Germline variants in the gene encoding each protein, as classified by GenCC submitters, each in their own words. Limited, disputed and refuted submissions are listed too.
- CEBPAHGNC:1833
- Definitive · ClinGen · Autosomal dominant · 2019
- Definitive · G2P · Autosomal dominant · 2016
- Strong · Genomics England PanelApp · Autosomal dominant · 2020
- Strong · Labcorp Genetics (formerly Invitae) · Autosomal dominant · 2022
- Moderate · Ambry Genetics · Autosomal dominant · 2022
- ANKRD26HGNC:29186
- Strong · Genomics England PanelApp · Autosomal dominant · 2020
- ETV6HGNC:3495
- Strong · Genomics England PanelApp · Autosomal dominant · 2020
- Limited · Ambry Genetics · Unknown · 2015
- GATA2HGNC:4171
Where it sits
- A kind of
- Narrower terms (78)
- acute leukemia of ambiguous lineage
- acute monocytic leukemia
- acute myeloid leukemia by FAB classification
- acute myeloid leukemia with 11q23 abnormalities
- acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22)
- acute myeloid leukemia with BCR-ABL1
- acute myeloid leukemia with CEBPA somatic mutations
- acute myeloid leukemia with inv3(p21;q26.2) or t(3;3)(p21;q26.2)
- acute myeloid leukemia with multilineage dysplasia
- acute myeloid leukemia with mutated NPM1
- acute myeloid leukemia with NPM1 somatic mutations
- acute myeloid leukemia with t(6;9)(p23;q34)
- acute myeloid leukemia with t(8;16)(p11;p13) translocation
- acute myeloid leukemia with t(8;21)(q22;q22) translocation
- acute myeloid leukemia with t(9;11)(p22;q23)
- acute myeloid leukemia, biallelic CEBPA gene mutation
Other names
25 names
Resolves to: acute myeloid leukemia
- Also called
- acute granulocytic leukaemiaacute granulocytic leukemiaacute myeloblastic leukemiaacute myelocytic leukaemiaacute myelocytic leukemiaacute myelogenous leukemiaacute myelogenous leukemiasacute myeloid leukaemia (AML)acute myeloid leukemia (AML)acute myeloid leukemia, somaticacute Nonlymphocytic leukaemiaacute Nonlymphocytic leukemiaAMLAML - acute myeloid leukaemiaAML - acute myeloid leukemiaANLL