acute monocytic leukemia
Findings
No curated finding names acute monocytic leukemia yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Acute monoblastic leukemia (AML-M5), is one of the most common subtypes of acute myeloid leukemia (AML) that is either comprised of more than 80% of monoblasts (AML-M5a) or 30-80% monoblasts with (pro)monocytic differentiation (AML-M5b). AML-M5 presents with asthenia, pallor, fever, and dizziness. Specific features of AML-M5 include hyperleukocytosis, propensity for extramedullary infiltrates, coagulation abnormalities including disseminated intravascular coagulation and neurological disorders. Leukemia cutis and gingival infiltration can also be seen. A characteristic translocation observed in AML-M5 is t(9;11).
Definition from the Mondo Disease Ontology (MONDO:0007896), read 2026-09-29. CC BY 4.0.
Features
20 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Acute monocytic leukemiaHPOHP:0004845
- Obligate (100% of cases)
- AnemiaHPOHP:0001903
- Frequent (30% to 79% of cases)
- Bone marrow hypercellularityHPOHP:0031020
- Frequent (30% to 79% of cases)
- Exertional dyspneaHPOHP:0002875
- Frequent (30% to 79% of cases)
- FatigueHPOHP:0012378
- Frequent (30% to 79% of cases)
- Increased total leukocyte countHPOHP:0001974
- Frequent (30% to 79% of cases)
- Increased total lymphocyte count
Show the remaining 8
- FeverHPOHP:0001945
- Occasional (5% to 29% of cases)
- Hypochromic anemiaHPOHP:0001931
- Occasional (5% to 29% of cases)
- Increased circulating lactate dehydrogenase concentrationHPOHP:0025435
- Occasional (5% to 29% of cases)
- OliguriaHPOHP:0100520
- Occasional (5% to 29% of cases)
- Periorbital edemaHPOHP:0100539
- Occasional (5% to 29% of cases)
- Progressive hearing impairmentHPOHP:0001730
- Occasional (5% to 29% of cases)
Where it sits
Other names
7 names
Resolves to: acute monocytic leukemia
- Also called
- acute monoblastic leukaemia and acute monocytic leukaemiaacute monocytic leukaemia (FAB M5B)acute monocytic leukemia (FAB M5B)acute monocytic leukemia, morphology (morphologic abnormality)AML M5leukemia, monocytic, malignantmonocytic leukemia, acute