acute myeloid leukemia with NPM1 somatic mutations
Findings
No curated finding names acute myeloid leukemia with NPM1 somatic mutations yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Acute myeloid leukemia with NPM1 somatic mutations is a subtype of acute myeloid leukemia with recurrent genetic abnormalities characterized by clonal proliferation of myeloid blasts harboring mutations of the NPM1 gene in the bone marrow, blood and other tissues. It is associated with multilineage dysplasia, involving the myeloid, monocytic, erythroid, and megakaryocytic cell lineages. Patients usually present with leukocytosis, thrombocytosis and nonspecific symptoms related to ineffective hematopoesis (fatigue, bleeding and bruising, recurrent infections, bone pain), with frequent extramedullary involvement typically presenting as gingival hyperplasia and lymphadenopathy.
Definition from the Mondo Disease Ontology (MONDO:0018437), read 2026-09-29. CC BY 4.0.
Where it sits
- A kind of
Other names
1 name
Resolves to: acute myeloid leukemia with NPM1 somatic mutations
- Also called
- AML with NPM1 somatic mutations