megakaryoblastic acute myeloid leukemia with t(1;22)(p13;q13)
Findings
No curated finding names megakaryoblastic acute myeloid leukemia with t(1;22)(p13;q13) yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Megakaryoblastic acute myeloid leukemia with t(1;22)(p13;q13) is a rare subtype of acute myeloid leukemia with recurrent cytogenetic abnormalities characterized by clonal proliferation of myeloid blasts with predominantly megakaryoblastic differentiation in the bone marrow and blood, often with extensive infiltration of the abdominal organs. It occurs typically in infants and usually presents with hepatosplenomegaly, anemia, thrombocytopenia and nonspecific symptoms related to ineffective hematopoesis (fatigue, bleeding and bruising, recurrent infections). Myelofibrosis and fibrosis of other infiltrated organs is also characteristic of this disease.
Definition from the Mondo Disease Ontology (MONDO:0018436), read 2026-09-29. CC BY 4.0.
Where it sits
- A kind of
Other names
1 name
Resolves to: megakaryoblastic acute myeloid leukemia with t(1;22)(p13;q13)
- Also called
- megakaryoblastic AML with t(1;22)(p13;q13)